Page 64 - MEGIN Book Of Abstracts - 2023

Linde, M E; Wesseling, P; Kouwenhoven, M C M; Klein, groups classified into having increasing or stable tumor
M; Würdinger, T; Barkhof, F; Geurts, J J G; Hillebrand, A; volume. Results show that brain activity was signifi-
Douw, L cantly increased in the tumor hemisphere in general,
and in peritumoral regions specifically. However, none
Brain Tumor Center Amsterdam, Cancer Center Amsterdam, of the measures and spatial levels of brain activity
Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, correlated with changes in tumor volume, nor did they
The Netherlands; Department of Radiology and Nuclear differ between patients with increasing versus stable
Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, tumor volumes. Longitudinal studies in more homoge-
Amsterdam, The Netherlands; Department of Neurology, Am- neous subgroups of glioma patients are necessary to
sterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The further explore the clinical potential of non-invasively
Netherlands; Department of Clinical Neurophysiology and measured brain activity.
MEG Center, Amsterdam UMC, Vrije Universiteit Amsterdam,
Amsterdam, The Netherlands; Department of Neurosurgery, Scientific reports (2021), Vol. 11, No. 1 (34556701) (2
Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, citations)
The Netherlands; Department of Radiotherapy, Amsterdam
UMC, Vrije Universiteit Amsterdam, Amsterdam, The Neth-
erlands; Department of Pathology, Amsterdam UMC, Vrije Understanding Global Brain Network Alterations in
Universiteit Amsterdam, Amsterdam, The Netherlands; De- Glioma Patients (2021)
partment of Medical Psychology, Amsterdam UMC, Vrije Uni-
versiteit Amsterdam, Amsterdam, The Netherlands; Institutes Derks, Jolanda; Kulik, Shanna D; Numan, Tianne; de
of Neurology and Healthcare Engineering, University College Witt Hamer, Philip C; Noske, David P; Klein, Martin;
London, London, UK; Department of Anatomy and Neurosci- Geurts, Jeroen J G; Reijneveld, Jaap C; Stam, Cornelis J;
ences, Amsterdam UMC, Vrije Universiteit Amsterdam, O|2 Schoonheim, Menno M; Hillebrand, Arjan; Douw, Linda
building 13W09, De Boelelaan 1108, 1081 HV, Amsterdam,
The Netherlands; Brain Tumor Center Amsterdam, Cancer Brain Tumor Center Amsterdam, Amsterdam UMC, Vrije
Center Amsterdam, Amsterdam UMC, Vrije Universiteit Universiteit Amsterdam, Amsterdam, The Netherlands;
Amsterdam, Amsterdam, The Netherlands. l.douw@amster- Department of Neurosurgery, Overarching Institute, Amster-
damumc.nl dam UMC, Vrije Universiteit Amsterdam, Amsterdam, The
Netherlands; Department of Medical Psychology, Overarch-
ABSTRACT Non-invasively measured brain activity is ing Institute, Amsterdam UMC, Vrije Universiteit Amsterdam,
related to progression-free survival in glioma patients, Amsterdam, The Netherlands; Department of Anatomy and
suggesting its potential as a marker of glioma progres- Neurosciences, Amsterdam Neuroscience, Amsterdam UMC,
sion. We therefore assessed the relationship between Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;
brain activity and increasing tumor volumes on routine Department of Neurology, Overarching Institute, Amster-
clinical magnetic resonance imaging (MRI) in glioma dam UMC, Vrije Universiteit Amsterdam, Amsterdam, The
patients. Postoperative magnetoencephalography Netherlands; Department of Clinical Neurophysiology and
(MEG) was recorded in 45 diffuse glioma patients. Brain MEG Center, Amsterdam Neuroscience, Amsterdam UMC,
activity was estimated using three measures (abso- Vrije Universiteit Amsterdam, Amsterdam, The Netherlands;
lute broadband power, offset and slope) calculated at Department of Radiology, Athinoula A. Martinos Center
three spatial levels: global average, averaged across for Biomedical Imaging/Massachusetts General Hospital,
the peritumoral areas, and averaged across the homo- Charlestown, Massachusetts, USA
logues of these peritumoral areas in the contralateral
hemisphere. Tumors were segmented on MRI. Changes ABSTRACT Introduction: Glioma patients show
in tumor volume between the two scans surrounding increased global brain network clustering related to
the MEG were calculated and correlated with brain poorer cognition and epilepsy. However, it is unclear
activity. Brain activity was compared between patient whether this increase is spatially widespread, local-

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