Page 68 - MEGIN Book Of Abstracts - 2023

686 Bay Street, Toronto, ON M5G 0A4, Canada. Electronic Keywords: Cognitive control, Exercise, Functional connec-
address: [email protected]; Neurosciences & tivity, Magnetoencephalography, Pediatric brain tumors
Mental Health, SickKids, 686 Bay Street, Toronto, ON M5G
0A4, Canada. Electronic address: [email protected]; Clinical neurophysiology: official journal of the
Neurosciences & Mental Health, SickKids, 686 Bay Street, International Federation of Clinical Neurophysiology
Toronto, ON M5G 0A4, Canada. Electronic address: harasyd@ (2020), Vol. 131, No. 7 (32403066) (10 citations)
mcmaster.ca; Neurosciences & Mental Health, SickKids, 686
Bay Street, Toronto, ON M5G 0A4, Canada; Department
of Psychology, University of Toronto, 100 St. George Street, Presurgical Functional Mapping with
Toronto, ON M5S 3G3, Canada. Electronic address: donald. Magnetoencephalography (2020)
[email protected]
Bowyer, Susan M; Pang, Elizabeth W; Huang, Mingxiong;
OBJECTIVE To assess the efficacy of aerobic exercise Papanicolaou, Andrew C; Lee, Roland R
training to improve controlled attention, information
processing speed and neural communication during MEG Lab, Henry Ford Hospital, Wayne State University, CFP
increasing task load and rest in pediatric brain tumor 079, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
survivors (PBTS) treated with cranial radiation. Electronic address: [email protected]; Division of Neurol-
ogy, Hospital for Sick Children, University of Toronto, 555
METHODS Participants completed visual-motor Go University Avenue, Toronto, Ontario M5G 1X8, Canada; UCSD
and Go/No-Go tasks during magnetoencephalography Radiology Imaging Laboratory, University of California San
recording prior to and following the completion of Diego, VA San Diego Healthcare System, 3510 Dunhill Street,
12-weeks of exercise training. Exercise-related changes San Diego, CA 92121, USA; The University of Tennessee, Col-
in response accuracy and visual-motor latency were lege of Medicine, 910 Madison Avenue # 1002, Memphis, TN
evaluated with Linear Mixed models. The Phase Lag 38103, USA
Index (PLI) was used to estimate functional connectivity
during task performance and rest. Changes in PLI val- ABSTRACT Noninvasive functional brain imaging with
ues after exercise training were assessed using Partial magnetoencephalography (MEG) is regularly used to
Least Squares analysis. map the eloquent cortex associated with somatosen-
sory, motor, auditory, visual, and language processing
RESULTS Exercise training predicted sustained before a surgical resection to determine if the func-
(12-weeks) improvement in response accuracy (p<0.05) tional areas have been reorganized. Most tasks can also
during No-Go trials. Altered functional connectivity be performed in the pediatric population. To acquire
was detected in theta (4-7Hz) alpha (8-12Hz) and high an optimal MEG study for any of these modalities, the
gamma (60-100Hz) frequency bands (p<0.001) during patient needs to be well rested and attending to the
Go and Go/No-Go trials. Significant changes in re- stimulation.
sponse latency and resting state connectivity were not
detected. Keywords: Auditory evoked magnetic fields, Language
evoked magnetic fields, Magnetoencephalography, Map-
CONCLUSION These findings support the efficacy of ping, Motor evoked magnetic fields, Presurgical, Somato-
aerobic exercise to improve controlled attention and sensory evoked magnetic fields, Visual evoked magnetic
enhance functional mechanisms under increasing task fields
load in participants.
Neuroimaging clinics of North America (2020), Vol. 30, No.
SIGNIFICANCE It may be possible to harness the ben- 2 (32336404) (4 citations)
eficial effects of exercise as therapy to promote cogni-
tive recovery and enhance brain function in PBTS.

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