Page 71 - MEGIN Book Of Abstracts - 2023

used in the analysis. Furthermore, combining MEG and INTRODUCTION Progression-free survival (PFS) in
fMRI showed the potential for increased motor map- glioma patients varies widely, even when stratifying for
ping accuracy compared to when using the modalities known predictors (i.e. age, molecular tumor subtype,
separately.Clinical trial registration no.: NCT01535430 presence of epilepsy, tumor grade and Karnofsky per-
(clinicaltrials.gov). formance status). Neuronal activity has been shown to
accelerate tumor growth in an animal model, suggest-
Keywords: BVS = blood vessel segmentation, DCS = direct ing that brain activity may be valuable as a PFS predic-
cortical stimulation, MEG, MEG = magnetoencephalog- tor. We investigated whether postoperative oscillatory
raphy, T1W = T1-weighted, brain mapping, brain tumor, brain activity, assessed by resting-state magnetoen-
eloquent, fMRI, fMRI = functional MRI cephalography is of additional value when predicting
PFS in glioma patients.
Neurosurgical focus (2020), Vol. 48, No. 2 (32006951) (12
citations) METHODS We included 27 patients with grade II-IV
gliomas. Each patient's oscillatory brain activity was
estimated by calculating broadband power (0.5-48 Hz)
Postoperative oscillatory brain activity as an add-on in 56 epochs of 3.27 s and averaged over 78 cortical
prognostic marker in diffuse glioma (2020) regions of the Automated Anatomical Labeling atlas.
Cox proportional hazard analysis was performed to test
Belgers, Vera; Numan, Tianne; Kulik, Shanna D; the predictive value of broadband power towards PFS,
Hillebrand, Arjan; de Witt Hamer, Philip C; Geurts, adjusting for known predictors by backward elimina-
Jeroen J G; Reijneveld, Jaap C; Wesseling, Pieter; Klein, tion.
Martin; Derks, Jolanda; Douw, Linda
RESULTS Higher broadband power predicted shorter
Brain Tumor Center, Cancer Center Amsterdam, Amsterdam PFS after adjusting for known prognostic factors
UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 (n = 27; HR 2.56 (95% confidence interval (CI) 1.15-
HV, Amsterdam, Netherlands; Clinical Neurophysiology and 5.70); p = 0.022). Post-hoc univariate analysis showed
MEG Center, Amsterdam Neuroscience, Amsterdam UMC, that higher broadband power also predicted shorter
Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, overall survival (OS; n = 38; HR 1.88 (95% CI 1.00-3.54);
Amsterdam, Netherlands; Neurosurgery, Amsterdam Neuro- p = 0.038).
science, Amsterdam UMC, Vrije Universiteit Amsterdam, De
Boelelaan 1117, 1081 HV, Amsterdam, Netherlands; Anatomy CONCLUSIONS Our findings suggest that postopera-
& Neurosciences, Amsterdam Neuroscience, Amsterdam tive broadband power is of additional value in predict-
UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, ing PFS beyond already known predictors.
1081 HV, Amsterdam, Netherlands; Neurology, Amsterdam
Neuroscience, Amsterdam UMC, Vrije Universiteit Amster- Keywords: Beamforming, Glioma, Magnetoencephalogra-
dam, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands; phy (MEG), Overall survival, Progression-free survival
Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije
Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amster- Journal of neuro-oncology (2020), Vol. 147, No. 1
dam, Netherlands; Medical Psychology, Amsterdam Neuro- (31953611) (6 citations)
science, Amsterdam UMC, Vrije Universiteit Amsterdam, De
Boelelaan 1117, 1081 HV, Amsterdam, Netherlands; Depart-
ment of Radiology, Athinoula A. Martinos Center for Biomedi-
cal Imaging, Massachusetts General Hospital, 149 13th street,
Charlestown, MA, USA. [email protected]

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