Page 74 - MEGIN Book Of Abstracts - 2023

Dementia

Early visual alterations in individuals at-risk of ophthalmological measures, as well as in resting-state
Alzheimer's disease: a multidisciplinary approach electrophysiological activity. However, it is unknown
(2023) whether the ophthalmological alterations are related to
the visual-related electrophysiological activity. Elucidat-
López-Cuenca, Inés; Nebreda, Alberto; García-Colomo, ing this relationship is paramount to understand the
Alejandra; Salobrar-García, Elena; de Frutos-Lucas, mechanisms underlying the early deterioration of the
Jaisalmer; Bruña, Ricardo; Ramírez, Ana I; Ramirez- system and an important step in assessing the suitabil-
Toraño, Federico; Salazar, Juan J; Barabash, Ana; Gil, ity of these measures as early biomarkers of disease.
Pedro; Maestú, Fernando; Ramírez, José M; de Hoz, Rosa
METHODS In total, 144 healthy subjects: 105 with
Health Research Institute of the Hospital Clínico San Carlos family history of AD and 39 without, underwent
(IdISSC), 28040, Madrid, Spain; Department of Experimental ophthalmologic analysis, magnetoencephalography
Psychology, Cognitive Psychology and Speech & Language recording, and genotyping. A subdivision was made to
Therapy, Complutense University of Madrid, 28223, Pozuelo compare groups with less demographic and more risk
de Alarcón, Spain; Department of Experimental Psychol- differences: 28 high-risk subjects (relatives/APOE∼4 +)
ogy, Cognitive Psychology and Speech & Language Therapy, and 16 low-risk (non-relatives/APOE∼4 -). Differences in
Complutense University of Madrid, 28223, Pozuelo de Alar- visual acuity, contrast sensitivity, and macular thickness
cón, Spain. [email protected]; Department of Immunology, were evaluated. Correlations between each variable
Ophthalmology and ENT, Faculty of Optics and Optometry, and visual-related electrophysiological measures (M100
University of Madrid, 28040, Madrid, Spain; Department latency and time-frequency power) were calculated for
of Psychology, Nebrija University, 28015, Madrid, Spain; each group.
Department of Radiology, Complutense University of Madrid,
28040, Madrid, Spain; Department of Medicine II, School of RESULTS High-risk groups showed increased visual
Medicine, Complutense University of Madrid, 28040, Madrid, acuity. Visual acuity was also related to a lower M100
Spain; Memory Unit, Geriatrics Service, Hospital Clínico San latency and a greater power time-frequency cluster in
Carlos, 28040, Madrid, Spain; Biomedical Research Network- the high-risk group. Low-risk groups did not show this
ing Center in Bioengineering, Biomaterials and Nanomedi- relationship. High-risk groups presented trends towards
cine, 28029, Madrid, Spain; Department of Immunology, a greater contrast sensitivity that did not remain sig-
Ophthalmology and ENT, Faculty of Medicine, Complutense nificant after correction for multiple comparisons. The
University of Madrid, 28040, Madrid, Spain; Department of highest-risk group showed trends towards the thinning
Immunology, Ophthalmology and ENT, Faculty of Optics of the inner plexiform and inner nuclear layers that did
and Optometry, University of Madrid, 28040, Madrid, Spain. not remain significant after correction. The correlation
[email protected] between contrast sensitivity and macular thickness,
and the electrophysiological measures were not signifi-
BACKGROUND The earliest pathological features of cant after correction. The difference between the high-
Alzheimer's disease (AD) appear decades before the and low- risk groups correlations was no significant.
clinical symptoms. The pathology affects the brain
and the eye, leading to retinal structural changes and CONCLUSIONS To our knowledge, this paper is the first
functional visual alterations. Healthy individuals at of its kind, assessing the relationship between ophthal-
high risk of developing AD present alterations in these mological and electrophysiological measures in healthy

 ontents  Index 53
C