Page 72 - MEGIN Book Of Abstracts - 2023

Spatiotemporal dynamics of postoperative Together, these results suggest that postoperative lan-
functional plasticity in patients with brain tumors in guage functional reorganization occurs in peritumoral
language areas (2020) regions regardless of the location of the tumor and
mostly develops within 3 months after surgery.
Lizarazu, Mikel; Gil-Robles, Santiago; Pomposo, Iñigo;
Nara, Sanjeev; Amoruso, Lucía; Quiñones, Ileana; Keywords: Functional connectivity, Functional reorganiza-
Carreiras, Manuel tion, Language networks, Low-grade glioma, Magnetoen-
cephalography
BCBL, Basque Center on Cognition, Brain and Language,
Donostia/San Sebastián, Spain; Laboratoire de Sciences Brain and language (2020), Vol. 202 (31931399) (13
Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Ecole citations)
Normale Supérieure, PSL Research University, Paris, France.
Electronic address: [email protected]; Department of
Neurosurgery, Hospital Quirón, Madrid, Spain; BioCruces Re- Refined Functional Magnetic Resonance Imaging
search Institute, Bilbao, Spain; BCBL, Basque Center on Cogni- and Magnetoencephalography Mapping Reveals
tion, Brain and Language, Donostia/San Sebastián, Spain; Reorganization in Language-Relevant Areas of
Ikerbasque, Basque Foundation for Science, Bilbao, Spain; Lesioned Brains (2020)
University of the Basque Country, UPV/EHU, Bilbao, Spain
Zimmermann, Max; Rössler, Karl; Kaltenhäuser, Martin;
ABSTRACT Postoperative functional neuroimaging Grummich, Peter; Yang, Bing; Buchfelder, Michael;
provides a unique opportunity to investigate the neural Doerfler, Arnd; Kölble, Konrad; Stadlbauer, Andreas
mechanisms that facilitate language network reorga-
nization. Previous studies in patients with low grade Department of Neurosurgery, University of Erlangen-Nürn-
gliomas (LGGs) in language areas suggest that postop- berg, Erlangen, Germany; Department of Neuroradiology,
erative recovery is likely due to functional neuroplasti- University of Erlangen-Nürnberg, Erlangen, Germany. Elec-
city in peritumoral and contra-tumoral healthy regions, tronic address: [email protected]; Depart-
but have attributed varying degrees of importance ment of Neurosurgery, University of Erlangen-Nürnberg,
to specific regions. In this study, we used Magnetoen- Erlangen, Germany; Department of Neurosurgery, Medical
cephalography (MEG) to investigate functional con- University Vienna, Vienna, Austria; Department of Neuropa-
nectivity changes in peritumoral and contra-tumoral thology, University of Erlangen-Nürnberg, Erlangen, Ger-
regions after brain tumor resection. MEG recordings many; Department of Neurosurgery, University of Erlangen-
of cortical activity during resting-state were obtained Nürnberg, Erlangen, Germany; Institute of Medical Radiology,
from 12 patients with LGGs in left-hemisphere lan- University Clinic of St. Pölten, St. Pölten, Austria
guage brain areas. MEG data were recorded before (Pre
session), and 3 (Post_1 session) and 6 (Post_2 session) BACKGROUND Neurosurgical decisions regarding in-
months after awake craniotomy. For each MEG session, terventions close to brain areas with language-related
we measured the functional connectivity of the peri- functions remain highly challenging because of the
tumoral and contra-tumoral regions to the rest of the risk of postoperative dysfunction. To minimize these
brain across the 1-100 Hz frequency band. We found risks, improvements in the preoperative mapping of
that functional connectivity in the Post_1 and Post_2 language-related regions are required, especially as
sessions was higher than in the Pre session only in peri- space-occupying lesions often lead to altered cortical
tumoral regions and within the alpha frequency band. topography and language area reorganization.
Functional connectivity in peritumoral regions did not
differ between the Post_1 and Post_2 sessions. Alpha METHODS The degree of deviation and language
connectivity enhancement in peritumoral regions was area reorganization were investigated in 26 functional
observed in all patients regardless of the LGG location. magnetic resonance imaging- and magnetoenceph-

 ontents  Index 51
C