Page 75 - MEGIN Book Of Abstracts - 2023

subjects at distinct levels of risk of AD. The results are ral and neuropsychological bases. In the current study,
novel and unexpected, showing an increase in visual we begin to address this knowledge gap by recording
acuity among high-risk subjects, who also exhibit a magnetoencephalography (MEG) during a flanker inter-
relationship between this measure and visual-related ference task in 31 biomarker-confirmed patients on the
electrophysiological activity. These results have not AD spectrum (ADS), 25 older participants with HAND,
been previously explored and could constitute a useful and 31 cognitively-normal controls. MEG data was
object of research as biomarkers for early detection and examined in the time-frequency domain using a data-
the evaluation of potential interventions' effectiveness. driven approach. Our results indicated that the clinical
groups (ADS/HAND) performed significantly worse
Keywords: Alzheimer’s disease, At risk for AD, Magneto- than controls on the task and exhibited aberrations in
encephalography, Optical coherence tomography, Visual interference-related theta and alpha oscillations, some
function of which were disease-specific. Specifically, patients
(ADS/HAND) exhibited weaker interference activity
Alzheimer's research & therapy (2023), Vol. 15, No. 1 in frontoparietal and cingulate cortices compared to
(36694201) (0 citations) controls, while the ADS group exhibited stronger theta
interference than those with HAND in frontoparietal,
occipital, and temporal cortices. These results reveal
Oscillatory markers of neuroHIV-related cognitive overlapping and distinct patterns of neurophysiological
impairment and Alzheimer's disease during alterations among those with ADS and HAND in atten-
attentional interference processing (2023) tional processing centers and suggest the existence of
unique oscillatory markers of each condition.
Meehan, Chloe E; Schantell, Mikki; Wiesman, Alex I;
Wolfson, Sara L; O'Neill, Jennifer; Bares, Sara H; Johnson, Keywords: MEG, magnetoencephalography, neuroHIV,
Craig M; May, Pamela E; Murman, Daniel L; Wilson, Tony oscillations, top-down
W
Aging (2023), Vol. 15, No. 2 (36656738) (0 citations)
Department of Psychology, University of Nebraska – Omaha,
Omaha, NE 68182, USA; College of Medicine, University of
Nebraska Medical Center, Omaha, NE 68198, USA; Montreal New Therapeutics in Alzheimer's Disease
Neurological Institute, McGill University, Montreal, QC H3A Longitudinal Cohort study (NTAD): study protocol
2B4, CA; Geriatrics Medicine Clinic, UNMC, Omaha, NE 68198, (2022)
USA; Department of Internal Medicine, Division of Infectious
Diseases, UNMC, Omaha, NE 68198, USA; Department of Lanskey, Juliette Helene; Kocagoncu, Ece; Quinn,
Radiology, UNMC, Omaha, NE 68198, USA; Department of Andrew J; Cheng, Yun-Ju; Karadag, Melek; Pitt, Jemma;
Neurological Sciences, UNMC, Omaha, NE 68198, USA; Mem- Lowe, Stephen; Perkinton, Michael; Raymont, Vanessa;
ory Disorders and Behavioral Neurology Program, UNMC, Singh, Krish D; Woolrich, Mark; Nobre, Anna C; Henson,
Omaha, NE 68198, USA; Department of Pharmacology and Richard N; Rowe, James B; NTAD study group
Neuroscience, Creighton University, Omaha, NE 68178, USA
MRC Cognition and Brain Sciences Unit, University of
ABSTRACT People with HIV (PWH) frequently experi- Cambridge, Cambridge, UK [email protected].
ence mild cognitive decline, which is typically attribut- ac.uk; Department of Clinical Neurosciences and Cambridge
ed to HIV-associated neurocognitive disorder (HAND). University Hospitals NHS Foundation Trust, Cambridge Bio-
However, such declines could also be a sign of early medical Campus, University of Cambridge, Cambridge, UK;
Alzheimer's disease (AD) in older PWH. Distinguishing Oxford Centre for Human Brain Activity, Wellcome Centre for
these two pathologies in PWH is exceedingly difficult, Integrative Neuroimaging, Department of Psychiatry, Univer-
as there is a major knowledge gap regarding their neu- sity of Oxford, Oxford, UK; Lilly Corporate Center, Indianapolis,

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C