Page 67 - MEGIN Book Of Abstracts - 2023

to identify visual cortex and potentially tailor surgical as lesion-induced impairment of NVC. In these brain
resections. regions with impaired NVC, physiologic MRI revealed
significant brain tissue hypoxia, as well as significantly
Journal of clinical neurophysiology: official publication decreased macro- and microvascular perfusion and
of the American Electroencephalographic Society (2020), microvascular architecture. We demonstrated that
Vol. 37, No. 6 (33165231) (4 citations) perilesional hypoxia with reduced vascular perfusion
and architecture is associated with lesion-induced
impairment of NVC. Our physiologic MRI approach is
Association between tissue hypoxia, perfusion a clinically applicable method for preoperative risk as-
restrictions, and microvascular architecture sessment for the presence of false-negative fMRI results
alterations with lesion-induced impairment of and may prevent severe postoperative functional
neurovascular coupling (2022) deficits.

Stadlbauer, Andreas; Kinfe, Thomas M; Zimmermann, Keywords: Blood-oxygen-level-dependent contrast, func-
Max; Eyüpoglu, Ilker; Brandner, Nadja; Buchfelder, tional magnetic resonance imaging, hypoxia, magnetoen-
Michael; Zaiss, Moritz; Dörfler, Arnd; Brandner, cephalography, neurovascular coupling
Sebastian
Journal of cerebral blood flow and metabolism: official
Institute of Medical Radiology, University Clinic of St. Pölten, journal of the International Society of Cerebral Blood
St. Pölten, Austria; Division of Functional Neurosurgery and Flow and Metabolism (2022), Vol. 42, No. 3 (32787542) (3
Stereotaxy, Friedrich-Alexander University (FAU) of Erlangen- citations)
Nürnberg, Erlangen, Germany; Department of Preclinical Im-
aging and Radiopharmacy, University of Tübingen, Tübingen,
Germany; Department of Neurosurgery, Friedrich-Alexander A controlled clinical crossover trial of exercise
University (FAU) of Erlangen-Nürnberg, Erlangen, Germany; training to improve cognition and neural
Department of Neuroradiology, Friedrich-Alexander Univer- communication in pediatric brain tumor survivors
sity of Erlangen-Nürnberg, Erlangen, Germany (2020)

ABSTRACT Functional magnetic resonance imaging Cox, Elizabeth; Bells, Sonya; Timmons, Brian W;
(fMRI) has been mainly utilized for the preoperative Laughlin, Suzanne; Bouffet, Eric; de Medeiros, Cynthia;
localization of eloquent cortical areas. However, lesion- Beera, Kiran; Harasym, Diana; Mabbott, Donald J
induced impairment of neurovascular coupling (NVC)
in the lesion border zone may lead to false-negative Neurosciences & Mental Health, SickKids, 686 Bay Street,
fMRI results. The purpose of this study was to deter- Toronto, ON M5G 0A4, Canada; Department of Psychology,
mine physiological factors impacting the NVC. Twenty University of Toronto, 100 St. George Street, Toronto, ON M5S
patients suffering from brain lesions were preopera- 3G3, Canada. Electronic address: elizabeth.cox@sickkids.
tively examined using multimodal neuroimaging in- ca; Neurosciences & Mental Health, SickKids, 686 Bay Street,
cluding fMRI, magnetoencephalography (MEG) during Toronto, ON M5G 0A4, Canada. Electronic address: sonya.
language or sensorimotor tasks (depending on lesion [email protected]; Department of Pediatrics, McMaster Uni-
location), and a novel physiologic MRI approach for the versity, 1200 Main Street W., Hamilton, ON L8N 3Z5, Canada.
combined quantification of oxygen metabolism, perfu- Electronic address: [email protected]; Diagnostic
sion state, and microvascular architecture. Congruence Imaging, SickKids, 555 University Avenue, Toronto, ON M5G
of brain activity patterns between fMRI and MEG were 1X8, Canada. Electronic address: suzanne.laughlin@sickkids.
found in 13 patients. In contrast, we observed missing ca; Neurosciences & Mental Health, SickKids, 686 Bay Street,
fMRI activity in perilesional cortex that demonstrated Toronto, ON M5G 0A4, Canada. Electronic address: eric.
MEG activity in seven patients, which was interpreted [email protected]; Neurosciences & Mental Health, SickKids,

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