Page 85 - MEGIN Book Of Abstracts - 2023

appear in the IWOC individuals, suggesting that their and neuropsychological scores were acquired before
condition is not part of the AD continuum. This work and after a ten-week COGTR intervention aimed at
raises interesting questions about this group of indi- improving cognitive function and daily living perfor-
viduals, and the underlying brain mechanisms behind mance. Functional connectivity (FC) was analyzed using
their cognitive impairment. the phase-locking value. A mixed-effects ANOVA model
with factors time (pre-intervention/post-intervention),
Keywords: Cluster-based permutation test, Mild cogni- training (trained/non-trained), and diagnosis (HC/SCD)
tive impairment, Source reconstruction, Spectral power was used to investigate significant changes in FC.
analysis, magnetoencephalography
RESULTS We found an average increase in alpha-band
Clinical EEG and neuroscience (2023), Vol. 54, No. 1 FC over time, but the effect was different in each group
(35188831) (2 citations) (trained and non-trained). In the trained group (HC and
SCD), we report a reduction in the increase in FC within
temporo-parietal and temporo-occipital connections.
Cognitive Training Modulates Brain Hypersynchrony In the trained SCD group, this reduction was stronger
in a Population at Risk for Alzheimer's Disease and showed a tentative correlation with improved
(2022) performance in different cognitive tests.

Suárez-Méndez, Isabel; Bruña, Ricardo; López-Sanz, CONCLUSION COGTR interventions could mitigate ab-
David; Montejo, Pedro; Montenegro-Peña, Mercedes; errant increases in FC in preclinical AD, promoting brain
Delgado-Losada, María Luisa; Marcos Dolado, Alberto; synchrony normalization in groups at a higher risk of
López-Higes, Ramón; Maestú, Fernando developing dementia.

Department of Experimental Psychology, Faculty of Psychol- Keywords: Cognitive decline, functional neuroimaging,
ogy, Complutense University of Madrid (UCM), Madrid, Spain; intervention study, longitudinal studies, magnetoen-
Center for the Prevention of Cognitive Impairment (Madrid cephalography
Salud), Madrid City Council, Madrid, Spain; Neurology De-
partment, Clinic San Carlos Hospital, Madrid, Spain Journal of Alzheimer's disease: JAD (2022), Vol. 86, No. 3
(35180120) (0 citations)
BACKGROUND Recent studies demonstrated that
brain hypersynchrony is an early sign of dysfunction in
Alzheimer's disease (AD) that can represent a proxy for Spatially resolved neural slowing predicts
clinical progression. Conversely, non-pharmacological impairment and amyloid burden in Alzheimer's
interventions, such as cognitive training (COGTR), are disease (2022)
associated with cognitive gains that may be under-
pinned by a neuroprotective effect on brain synchrony. Wiesman, Alex I; Murman, Daniel L; Losh, Rebecca
A; Schantell, Mikki; Christopher-Hayes, Nicholas J;
OBJECTIVE To study the potential of COGTR to modu- Johnson, Hallie J; Willett, Madelyn P; Wolfson, Sara
late brain synchrony and to eventually revert the hyper- L; Losh, Kathryn L; Johnson, Craig M; May, Pamela E;
synchrony phenomenon that characterizes preclinical Wilson, Tony W
AD.
Department of Neurological Sciences, University of Nebraska
METHODS The effect of COGTR was examined in a Medical Center (UNMC), Omaha, NE, USA; Memory Disor-
sample of healthy controls (HC, n = 41, 22 trained) and ders & Behavioral Neurology Program, UNMC, Omaha, NE,
individuals with subjective cognitive decline (SCD, USA; Institute for Human Neuroscience, Boys Town National
n = 49, 24 trained). Magnetoencephalographic activity Research Hospital, Boys Town, NE, USA; Geriatrics Medicine

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