Page 88 - MEGIN Book Of Abstracts - 2023

Keywords: Cognitive decline, Dementia, Machine learning, Keywords: Alzheimer Disease, magnetoengephalography,
Magnetoencephalography, Multi-class classification pico-Tesla transcranial magnetic stimulation

Neurobiology of aging (2022), Vol. 111 (34906377) (0 Medicina (Kaunas, Lithuania) (2021), Vol. 57, No. 11
citations) (34833381) (0 citations)

Analyzing the Effect of Weak External Transcranial MEG activity of the dorsolateral prefrontal cortex
Magnetic Stimulation on the Primary Dominant during optic flow stimulations detects mild
Frequencies of Alzheimer Patients Brain by Using cognitive impairment due to Alzheimer's disease
MEG Recordings (2021) (2021)

Anninos, Photios; Adamopoulos, Adam; Anninou, Noguchi-Shinohara, Moeko; Koike, Masato; Morise,
Nikolia; Tsagas, Nikolaos Hirofumi; Kudo, Kiwamu; Tsuchimine, Shoko; Komatsu,
Junji; Abe, Chiemi; Kitagawa, Sachiko; Ikeda, Yoshihisa;
Laboratory of Medical Physics, Department of Medicine, Yamada, Masahito
Democritus University of Thrace, 68100 Alexandroupolis,
Greece; Private Sector Veterinarian, 68100 Alexandroupolis, Department of Preemptive Medicine of Dementia, Kanazawa
Greece; Department of Electrical Engineering, Democritus University Graduate School of Medical Sciences, Kanazawa
University of Thrace, 7100 Xanthi, Greece University, Kanazawa, Japan; Medical Imaging Business
Center, Ricoh Company, Ltd., Tokyo, Japan; Department of
ABSTRACT Backround and Objectives: Alternative, Neurology and Neurobiology of Aging, Kanazawa University
non-invasive, and non-pharmaceutical options are Graduate School of Medical Sciences, Kanazawa University,
gaining place in the battle of Alzheimer's Disease Kanazawa, Japan; Kudanzaka Hospital, Tokyo, Japan
treatment control. Lately, the magnetic stimulation of
the brain is the most prevalent technique with encour- ABSTRACT Dorsal stream, which has a neuronal con-
aging results. The aim of this study is to establish any nection with dorsolateral prefrontal cortex (DLPFC), is
possible change on the Primary Dominant Frequencies known to be responsible for detection of motion in-
(PDF) (range 2-7 Hz) of the affected brain regions in Al- cluding optic flow perception. Using magnetoencepha-
zheimer Disease (AD) patients after applying extremely lography (MEG), this study aimed to examine neural
weak Transcranial Magnetic Stimulation. Materials responses to optic flow stimuli with looming motion in
and Methods: For this purpose, all AD patients were the DLPFC in patients with mild cognitive impairment
scanned with the use of MagnetoEncephaloGraphy due to Alzheimer's disease (AD-MCI) compared with
(MEG) recordings through a whole-head 122-channel cognitively unimpaired participants (CU). We analyzed
MEG system. Results: Our results exerted statistically the neural responses by evaluating maximum source-
significant PDF changes due to weak TMS accompanied localized power for the AD-MCI group (n = 11) and CU
by rabid attenuation of clinical symptoms. Conclusion: (n = 20), focusing on six regions of interest (ROIs) that
Thus, this is the first time that a positive therapeutic form the DLPFC: right and left dorsal Brodmann area
effect is being demonstrated even at pico-Tesla range 9/46 (A9/46d), Brodmann area 46 (A46) and ventral
magnetic fields in a small clinical group of studies for Brodmann area 9/46 (A9/46v). We found significant dif-
AD. ferences in the maximum power between the groups
in the left A46 and A9/46v. Moreover, in the left A9/46v,
the maximum power significantly correlated with the
Wechsler Memory Scale-Revised general memory score
and delayed recall score. The maximum power in the
left A9/46v also revealed high performance in AD-MCI

 ontents  Index 67
C