Page 93 - MEGIN Book Of Abstracts - 2023

RESULTS Abnormal synchrony in alpha, but not in disease (AD) neuropathology in their fourth decade.
delta-theta, significantly predicted the NFT density at However, there is a lack of specific markers for charac-
post mortem neuropathological examination. terizing the disease stages while considering this popu-
lation's differential features. Methods: Forty-one DS
DISCUSSION Reduced alpha synchrony is a sensitive individuals participated in the study, and were classi-
neurophysiological index associated with pathological fied into three groups according to their clinical status:
tau, and a potential network biomarker for clinical tri- Alzheimer's disease (AD-DS), mild cognitive impairment
als, to gauge the extent of network dysfunction and the (MCI-DS), and controls (CN-DS). We performed an ex-
degree of rescue in treatments targeting tau pathways haustive neuropsychological evaluation and assessed
in AD. brain functional connectivity (FC) from magnetoen-
cephalographic recordings. Results: Compared with
Keywords: Alzheimer's disease, alpha oscillations, mag- CN-DS, both MCI-DS and AD-DS showed a pattern of
netoencephalography, neurofibrillary tangle density, increased FC within the high alpha band. The neuropsy-
neuropathology, neurophysiology chological assessment showed a generalized cognitive
impairment, especially affecting mnestic functions, in
Alzheimer's & dementia: the journal of the Alzheimer's MCI-DS and, more pronouncedly, in AD-DS. Discussion:
Association (2021), Vol. 17, No. 12 (33884753) (7 citations) These findings might help to characterize the AD-con-
tinuum in DS. In addition, they support the role of the
excitatory/inhibitory imbalance as a key pathophysi-
Hypersynchronized Magnetoencephalography ological factor in AD. Impact statement The pattern
Brain Networks in Patients with Mild Cognitive of functional connectivity (FC) hypersynchronization
Impairment and Alzheimer's Disease in Down found in this study resembles the largely reported Al-
Syndrome (2021) zheimer's disease (AD) FC evolution pattern in popula-
tion with typical development. This study supports the
Ramírez-Toraño, Federico; García-Alba, Javier; Bruña, hypothesis of the excitatory/inhibitory imbalance as a
Ricardo; Esteba-Castillo, Susanna; Vaquero, Lucía; key pathophysiological factor in AD, and its conclusions
Pereda, Ernesto; Maestú, Fernando; Fernández, Alberto could help in the characterization and prediction of
Down syndrome individuals with a greater likelihood of
Department of Experimental Psychology, Universidad Com- converting to dementia.
plutense de Madrid, Madrid, Spain; Research and Psychology
in Education Department, Complutense University of Madrid, Keywords: Alzheimer's disease, Down syndrome, func-
Madrid, Spain; Networking Research Center on Bioengineer- tional connectivity, hypersynchronization, magnetoen-
ing, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, cephalography, mild cognitive impairment
Spain; Specialized Department in Mental Health and
Intellectual Disability, Parc Hospitalari Martí i Julià-Institut Brain connectivity (2021), Vol. 11, No. 9 (33858203) (5
'd'Assistència Sanitària, Institut 'd'Assistència Sanitària (IAS), citations)
Girona, Spain; Department of Legal Medicine, Psychiatry and
Pathology, Complutense University of Madrid, Spain; Electri-
cal Engineering and Bioengineering Group, Department of Altered mismatch response precedes gray matter
Industrial Engineering and IUNE and ITB Universidad de La atrophy in subjective cognitive decline (2021)
Laguna, Santa Cruz de Tenerife, Spain; Institute of Sanitary
Investigation (IdISSC), San Carlos University Hospital, Madrid, Cheng, Chia-Hsiung; Chang, Chiung-Chih; Chao, Yi-
Spain Ping; Lu, Hsinjie; Peng, Shih-Wei; Wang, Pei-Ning

ABSTRACT Introduction: The majority of individuals Department of Psychiatry, Chang Gung Memorial Hospital,
with Down syndrome (DS) show signs of Alzheimer's Linkou, Taiwan; Department of Neurology and Institute for

 ontents  Index 72
C