Page 98 - MEGIN Book Of Abstracts - 2023

Keywords: DBS, DTI, MEG, coherence, oscillations sured with MEG. Correlations were sought between
temporal properties of HMM states and participants'
Brain: a journal of neurology (2021), Vol. 144, No. 3 cognitive test scores, whole hippocampal grey matter
(33521808) (14 citations) volume and regional brain glucose metabolism. The
posterior default-mode network (DMN) was less often
activated and for shorter durations in AD patients than
Alterations in resting-state network dynamics along matched healthy elders. No significant difference was
the Alzheimer's disease continuum (2020) found in patients with SCD or aMCI. The time spent by
participants in the activated posterior DMN state did
Puttaert, D; Coquelet, N; Wens, V; Peigneux, P; Fery, not correlate significantly with cognitive scores, nor
P; Rovai, A; Trotta, N; Sadeghi, N; Coolen, T; Bier, J-C; with the whole hippocampal volume. However, it corre-
Goldman, S; De Tiège, X lated positively with the regional glucose consumption
in the right dorsolateral prefrontal cortex (DLPFC). AD
Neuropsychology and Functional Neuroimaging Research patients present alterations of posterior DMN power
Unit (UR2NF), Center for Research in Cognition and Neurosci- activation dynamics at rest that identify an additional
ences (CRCN), UNI-ULB Neuroscience Institute, Université libre electrophysiological correlate of AD-related synaptic
de Bruxelles (ULB), Brussels, Belgium. delphine.puttaert@ulb. and neural dysfunction. The right DLPFC may play
ac.be; Laboratoire de Cartographie fonctionnelle du Cerveau a causal role in the activation of the posterior DMN,
(LCFC), UNI-ULB Neuroscience Institute, Université libre de possibly linked to the occurrence of mind wandering
Bruxelles (ULB), Brussels, Belgium; Department of Functional episodes. As such, these data might suggest a neural
Neuroimaging, Service of Nuclear Medicine, CUB Hôpital correlate of the decrease in mind wandering episodes
Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium; reported in pathological aging.
Service of Neuropsychology and Speech Therapy, CUB Hôpital
Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium; Scientific reports (2020), Vol. 10, No. 1 (33319785) (14
Department of Radiology, CUB Hôpital Erasme, Université citations)
libre de Bruxelles (ULB), Brussels, Belgium; Department of
Neurology, CUB Hôpital Erasme, Université libre de Bruxelles
(ULB), Brussels, Belgium Predicting the outcome of non-pharmacological
treatment for patients with dementia-related mild
ABSTRACT Human brain activity is intrinsically orga- cognitive impairment (2020)
nized into resting-state networks (RSNs) that transiently
activate or deactivate at the sub-second timescale. Few Shigihara, Yoshihito; Hoshi, Hideyuki; Poza, Jesús;
neuroimaging studies have addressed how Alzheimer's Rodríguez-González, Víctor; Gómez, Carlos; Kanzawa,
disease (AD) affects these fast temporal brain dynam- Takao
ics, and how they relate to the cognitive, structural and
metabolic abnormalities characterizing AD. We aimed MEG Centre, Kumagaya General Hospital, Kumagaya 360-
at closing this gap by investigating both brain structure 8567, Saitama, Japan; Precision Medicine Centre, Hokuto
and function using magnetoencephalography (MEG) Hospital, Obihiro 080-0833, Hokkaido, Japan; Instituto de
and hybrid positron emission tomography-magnetic Investigación en Matemáticas (IMUVA), University of Val-
resonance (PET/MR) in 10 healthy elders, 10 patients ladolid, Valladolid 47011, Castilla y León, Spain; Centro de
with subjective cognitive decline (SCD), 10 patients Investigación Biomédica en Red en Bioingeniería, Biomateria-
with amnestic mild cognitive impairment (aMCI) and 10 les y Nanomedicina, (CIBER-BBN), Valladolid 47011, Castilla y
patients with typical Alzheimer's disease with dementia León, Spain; Isesaki Clinic, Gunma, Isehara 372-0056, Gunma,
(AD). The fast activation/deactivation state dynamics Japan
of RSNs were assessed using hidden Markov modeling
(HMM) of power envelope fluctuations at rest mea-

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