Page 96 - MEGIN Book Of Abstracts - 2023

Keywords: GABA, conductance-based modelling, dynamic traditional structural imaging used routinely in clinical
causal modelling, frontotemporal dementia, progressive care, to include ultrahigh field MRI (7T MRI), magne-
supranuclear palsy toencephalography and PET with novel ligands. We
illustrate their potential as safe, robust and sufficiently
Brain: a journal of neurology (2021), Vol. 144, No. 7 scalable to be viable for experimental medicine studies
(33710299) (10 citations) and clinical trials. They are especially informative when
combined in multimodal studies, with model-based
analyses to test precisely defined hypotheses.
Advances in neuroimaging to support translational
medicine in dementia (2021) Keywords: MRI, PET, dementia, functional imaging, image
analysis
Cope, Thomas Edmund; Weil, Rimona Sharon; Düzel,
Emrah; Dickerson, Bradford C; Rowe, James Benedict Journal of neurology, neurosurgery, and psychiatry (2021),
Vol. 92, No. 3 (33568448) (4 citations)
Cambridge University Hospitals NHS Foundation Trust,
Cambridge, UK; Movement Disorders Centre, University
College London, London, UK; Institute of Cognitive Neurosci- In vivo tau pathology is associated with synaptic
ence, University College London, London, UK; Frontotemporal loss and altered synaptic function (2021)
Disorders Unit, Department of Neurology, Massachusetts
General Hospital and Harvard Medical School, Charlestown, Coomans, Emma M; Schoonhoven, Deborah N; Tuncel,
Massachusetts, USA Hayel; Verfaillie, Sander C J; Wolters, Emma E; Boellaard,
Ronald; Ossenkoppele, Rik; den Braber, Anouk;
ABSTRACT Advances in neuroimaging are ideally Scheper, Wiep; Schober, Patrick; Sweeney, Steven P;
placed to facilitate the translation from progress made Ryan, J Michael; Schuit, Robert C; Windhorst, Albert D;
in cellular genetics and molecular biology of neurode- Barkhof, Frederik; Scheltens, Philip; Golla, Sandeep S V;
generation into improved diagnosis, prevention and Hillebrand, Arjan; Gouw, Alida A; van Berckel, Bart N M
treatment of dementia. New positron emission tomog-
raphy (PET) ligands allow one to quantify neuropathol- Alzheimer Center Amsterdam, Department of Neurology,
ogy, inflammation and metabolism in vivo safely and Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Am-
reliably, to examine mechanisms of human disease sterdam UMC, Amsterdam, The Netherlands. e.coomans@
and support clinical trials. Developments in MRI-based amsterdamumc.nl; Department of Clinical Neurophysiology
imaging and neurophysiology provide complementary and MEG Center, Department of Neurology, Amsterdam Neu-
quantitative assays of brain function and connectivity, roscience, Vrije Universiteit Amsterdam, Amsterdam UMC,
for the direct testing of hypotheses of human patho- Amsterdam, The Netherlands; Department of Radiology &
physiology. Advances in MRI are also improving the Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit
quantitative imaging of vascular risk and comorbidi- Amsterdam, Amsterdam UMC, Amsterdam, The Nether-
ties. In combination with large datasets, open data and lands; Clinical Memory Research Unit, Lund University, Lund,
artificial intelligence analysis methods, new infor- Sweden; Center for Neurogenomics and Cognitive Research,
matics-based approaches are set to enable accurate Department of Functional Genomics, Faculty of Science, Vrije
single-subject inferences for diagnosis, prediction and Universiteit, Amsterdam, The Netherlands; Department of
treatment that have the potential to deliver precision Anaesthesiology, Vrije Universiteit Amsterdam, Amsterdam
medicine for dementia. Here, we show, through the use UMC, Amsterdam, The Netherlands; Rodin Therapeutics Inc.,
of critically appraised worked examples, how neuroim- Cambridge, MA, USA; UCL Institutes of Neurology and Health-
aging can bridge the gaps between molecular biology, care Engineering, London, UK
neural circuits and the dynamics of the core systems
that underpin complex behaviours. We look beyond

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