Page 99 - MEGIN Book Of Abstracts - 2023

ABSTRACT Dementia is a progressive cognitive syn- ing, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid,
drome, with few effective pharmacological treatments Comunidad de Madrid 28029, Spain; Biological and Health
that can slow its progress. Hence, non-pharmacological Psychology Department, Universidad Autonoma de Madrid,
treatments (NPTs) play an important role in improving Madrid, Comunidad de Madrid 28049, Spain; Facultad de
patient symptoms and quality of life. Designing the Psicología, Centro Universitario Villanueva, Madrid, Comu-
optimal personalised NPT strategy relies on objectively nidad de Madrid 28034, Spain; Facultad de Educación y
and quantitatively predicting the treatment outcome. Salud, Universidad Camilo José Cela, Madrid, Comunidad de
Magnetoencephalography (MEG) findings can reflect Madrid 28010, Spain; Sección Neurorradiología, Servicio de
the cognitive status of patients with dementia, and Diagnóstico por Imagen, Hospital Clínico San Carlos, Madrid,
thus potentially predict NPT outcome. In the pres- Comunidad de Madrid 28040, Spain; Centro de Investigación
ent study, 16 participants with cognitive impairment Biomédica en Red de Diabetes y Enfermedades Metabólicas
underwent NPT for several months. Their cognitive Asociadas, Madrid, Comunidad de Madrid 28029, Spain;
performance was evaluated based on the Mini-Mental Neurology Department, Hospital Clinico San Carlos and
State Examination and the Alzheimer's Disease As- Instituto de Investigación Sanitaria del Hospital Clínico San
sessment Scale - Cognitive at the beginning and end Carlos, Madrid, Comunidad de Madrid 28040, Spain
of the NPT period, while resting-state brain activity
was evaluated using MEG during the NPT period. Our ABSTRACT Alzheimer's disease (AD) studies on animal
results showed that the spectral properties of MEG models, and humans showed a tendency of the brain
signals predicted the changes in cognitive performance tissue to become hyperexcitable and hypersynchro-
scores. High frequency oscillatory intensity at the right nized, causing neurodegeneration. However, we know
superior frontal gyrus medial segment, opercular part little about either the onset of this phenomenon
of the inferior frontal gyrus, triangular part of the infe- or its early effects on functional brain networks. We
rior frontal gyrus, post central gyrus, and angular gyrus studied functional connectivity (FC) on 127 partici-
predicted the changes in cognitive performance scores. pants (92 middle-age relatives of AD patients and 35
Thus, resting-state brain activity may be a powerful tool age-matched nonrelatives) using magnetoencepha-
in designing personalised NPT. lography. FC was estimated in the alpha band in
areas known both for early amyloid accumulation
Keywords: dementia, mild cognitive impairment, non- and disrupted FC in MCI converters to AD. We found
pharmacological treatment, power spectrum, spectral a frontoparietal network (anterior cingulate cortex,
parameters dorsal frontal, and precuneus) where relatives of AD
patients showed hypersynchronization in high alpha
Aging (2020), Vol. 12, No. 23 (33289701) (6 citations) (not modulated by APOE-ε4 genotype) in comparison
to age-matched nonrelatives. These results represent
the first evidence of neurophysiological events causing
Functional Connectivity Hypersynchronization in early network disruption in humans, opening a new
Relatives of Alzheimer's Disease Patients: An Early perspective for intervention on the excitation/inhibi-
E/I Balance Dysfunction? (2021) tion unbalance.

Ramírez-Toraño, F; Bruña, R; de Frutos-Lucas, J; Keywords: early detection, excitation/inhibition unbal-
Rodríguez-Rojo, I C; Marcos de Pedro, S; Delgado- ance, magnetoencephalography, network disruption,
Losada, M L; Gómez-Ruiz, N; Barabash, A; Marcos, A; relatives of Alzheimer’s disease patients
López Higes, R; Maestú, F
Cerebral cortex (New York, N.Y.: 1991) (2021), Vol. 31, No. 2
Department of Experimental Psychology, Universidad (33108468) (9 citations)
Complutense de Madrid, Madrid, Comunidad de Madrid
28223, Spain; Networking Research Center on Bioengineer-

 ontents  Index 78
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