Page 104 - MEGIN Book Of Abstracts - 2023

Resting state activity and connectivity of the GPi to sensorimotor areas. We also found differences
nucleus basalis of Meynert and globus pallidus between the two disease groups: oscillatory power in
in Lewy body dementia and Parkinson's disease the low beta (13-22Hz) band was significantly higher
dementia (2020) in the globus pallidus in PDD patients compared to
DLB, and coherence in the high beta (22-35Hz) band
Gratwicke, James; Oswal, Ashwini; Akram, Harith; between the globus pallidus and lateral sensorimotor
Jahanshahi, Marjan; Hariz, Marwan; Zrinzo, Ludvic; cortex was significantly higher in DLB patients com-
Foltynie, Tom; Litvak, Vladimir pared to PDD. Overall, our findings reveal coherent
networks of the NBM/GPi region that are common to
Department of Clinical and Movement Neurosciences, UCL both DLB and PDD. Although the neurophysiological
Institute of Neurology and The National Hospital for Neurol- differences between the two conditions in this study
ogy and Neurosurgery, Queen Square, London, UK; Nuffield are confounded by systematic differences in DBS lead
Department of Clinical Neurosciences, John Radcliffe Hospi- trajectories and motor symptom severity, they lend
tal, Oxford, UK; Wellcome Centre for Human Neuroimaging, support to the hypothesis that DLB and PDD, though
UCL Institute of Neurology, 12 Queen Square, London, UK; closely related, are distinguishable from a neurophysi-
Department of Clinical and Movement Neurosciences, UCL ological perspective.
Institute of Neurology and The National Hospital for Neurol-
ogy and Neurosurgery, Queen Square, London, UK; Wellcome Keywords: Basal forebrain, Basal ganglia, Human, Network,
Centre for Human Neuroimaging, UCL Institute of Neurology, Pallidum
12 Queen Square, London, UK; Wellcome Centre for Human
Neuroimaging, UCL Institute of Neurology, 12 Queen Square, NeuroImage (2020), Vol. 221 (32711059) (10 citations)
London, UK. Electronic address: [email protected]

ABSTRACT Parkinson's disease dementia (PDD) and Spontaneous MEG activity of the cerebral cortex
dementia with Lewy bodies (DLB) are two related during eyes closed and open discriminates
diseases which can be difficult to distinguish. There is Alzheimer's disease from cognitively normal older
no objective biomarker which can reliably differenti- adults (2020)
ate between them. The synergistic combination of
electrophysiological and neuroimaging approaches Ikeda, Yoshihisa; Kikuchi, Mitsuru; Noguchi-Shinohara,
is a powerful method for interrogation of functional Moeko; Iwasa, Kazuo; Kameya, Masafumi; Hirosawa,
brain networks in vivo. We recorded bilateral local field Tetsu; Yoshita, Mitsuhiro; Ono, Kenjiro; Samuraki-
potentials (LFPs) from the nucleus basalis of Meynert Yokohama, Miharu; Yamada, Masahito
(NBM) and the internal globus pallidus (GPi) with
simultaneous cortical magnetoencephalography (MEG) Department of Neurology and Neurobiology of Aging,
in six PDD and five DLB patients undergoing surgery Kanazawa University Graduate School of Medical Sciences,
for deep brain stimulation (DBS) to look for differences Kanazawa, Japan; Department of Psychiatry and Neuro-
in underlying resting-state network pathophysiology. biology, Kanazawa University Graduate School of Medical
In both patient groups we observed spectral peaks in Sciences, Kanazawa, Japan; Department of Preemptive Medi-
the theta (2-8 Hz) band in both the NBM and the GPi. cine for Dementia, Kanazawa University Graduate School of
Furthermore, both the NBM and the GPi exhibited simi- Medical Sciences, Kanazawa, Japan; Department of Neurol-
lar spatial and spectral patterns of coupling with the ogy, NHO Hokuriku National Hospital, Nanto, Japan; Depart-
cortex in the two disease states. Specifically, we report ment of Neurology and Neurobiology of Aging, Kanazawa
two distinct coherent networks between the NBM/GPi University Graduate School of Medical Sciences, Kanazawa,
and cortical regions: (1) a theta band (2-8 Hz) network Japan. [email protected]
linking the NBM/GPi to temporal cortical regions, and
(2) a beta band (13-22 Hz) network coupling the NBM/

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