Page 106 - MEGIN Book Of Abstracts - 2023

versidad Autonoma de Madrid, 28049, Madrid, Spain; School ers, this profile is associated with improved cognition
of Pharmacy and Biomedical Sciences, Faculty of Health (working and episodic memory).
Sciences, Curtin Health Innovation Research Institute, Curtin
University, Bentley, Western Australia, 6102, Australia; Centro CONCLUSIONS PA could mitigate the increase in FC
Universitario Villanueva, Facultad de Psicología, 28034, (hypersynchronization) that characterizes preclinical
Madrid, Spain; Mind, Brain and Behavior Research Center AD, being beneficial for all individuals, especially ε4
(CIMCYC), Universidad de Granada, 18071, Granada, Spain; carriers.
Networking Research Center on Bioengineering, Biomateri-
als and Nanomedicine (CIBER-BBN), 28029, Madrid, Spain; Keywords: APOE, Alzheimer’s disease, MEG, Physical activ-
Centro de Investigación Biomédica en Red de Diabetes y ity, Synaptic function, Temporal lobe
Enfermedades Metabólicas Asociadas, 28040, Madrid, Spain;
Neurology Department, Hospital Clinico San Carlos and Alzheimer's research & therapy (2020), Vol. 12, No. 1
Instituto de Investigación Sanitaria del Hospital Clínico San (32331531) (15 citations)
Carlos, 28040, Madrid, Spain

BACKGROUND Neuronal hyperexcitability and hy- Non-pharmacological treatment changes brain
persynchrony have been described as key features of activity in patients with dementia (2020)
neurophysiological dysfunctions in the Alzheimer's
disease (AD) continuum. Conversely, physical activity Shigihara, Yoshihito; Hoshi, Hideyuki; Shinada, Keita;
(PA) has been associated with improved brain health Okada, Toyoji; Kamada, Hajime
and reduced AD risk. However, there is controversy
regarding whether AD genetic risk (in terms of APOE ε4 Department of Neurosurgery, Hokuto Hospital, Obihiro City,
carriage) modulates these relationships. The utilization Japan. [email protected]; Precision Medicine Centre,
of multiple outcome measures within one sample may Hokuto Hospital, Obihiro City, Japan; Geriatric Health Ser-
strengthen our understanding of this complex phe- vices Facility Kakehashi, Hokuto Hospital Group, Obihiro City,
nomenon. Japan; Department of Clinical Laboratory, Hokuto Hospital,
Obihiro City, Japan
METHOD The relationship between PA and functional
connectivity (FC) was examined in a sample of 107 ABSTRACT Non-pharmacological treatment (NPT)
healthy older adults using magnetoencephalography. improves cognitive functions and behavioural distur-
Additionally, we explored whether ε4 carriage modu- bances in patients with dementia, but the underlying
lates this association. The correlation between FC and neural mechanisms are unclear. In this observational
brain structural integrity, cognition, and mood was also study, 21 patients with dementia received NPTs for sev-
investigated. eral months. Patients were scanned using magnetoen-
cephalography twice during the NPT period to evaluate
RESULTS A relationship between higher PA and de- NPT effects on resting-state brain activity. Additionally,
creased FC (hyposynchrony) in the left temporal lobe cognitive functions and behavioural disturbances were
was observed among all individuals (across the whole measured using the Mini-Mental State Examination
sample, in ε4 carriers, and in ε4 non-carriers), but its (MMSE-J) and a short version of the Dementia Behav-
effects manifest differently according to genetic risk. iour Disturbance Scale (DBD-13) at the beginning and
In ε4 carriers, we report an association between this the end of the NPT period. In contrast to the average
region-specific FC profile and preserved brain structure DBD-13 score, the average MMSE-J score improved
(greater gray matter volumes and higher integrity of after the NPT period. Magnetoencephalography data
white matter tracts). In this group, decreased FC also revealed a reduced alpha activity in the right tempo-
correlated with reduced anxiety levels. In ε4 non-carri- ral lobe and fusiform gyrus, as well as an increased
low-gamma activity in the right angular gyrus. DBD-13

 ontents  Index 85
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