Page 111 - MEGIN Book Of Abstracts - 2023

Depression

Gamma band VMPFC-PreCG.L connection variation compared to UD and HC. BD was applied to explore
after the onset of negative emotional stimuli can whether such abnormality is still significant between
predict mania in depressive patients (2023) every two groups of BD, tBD, UD, and HC.

Tao, Pengyu; Dai, Zhongpeng; Shao, Junneng; Tang, RESULTS The VMPFC-PreCG.L connection was found
Hao; Zhang, Siqi; Yao, Zhijian; Lu, Qing to be a significantly different connection between tBD
and UD in the early time period and between tBD and
School of Biological Sciences & Medical Engineering, South- BD in the middle time period. Furthermore, the middle/
east University, Nanjing, 210096, China; Child Development early time period ratio of FC value of VMPFC-PreCG.L
and Learning Science, Key Laboratory of Ministry of Educa- connection was negatively correlated with the bipolar-
tion, China; Department of Psychiatry, The Affiliated Brain ity index in tBD.
Hospital of Nanjing Medical University, Nanjing, 210029,
China; Nanjing Brain Hospital, Medical School of Nanjing CONCLUSIONS The VMPFC-PreCG.L connection in
University, Nanjing, 210093, China; Department of Psychiatry, different time periods after the onset of sad facial
The Affiliated Brain Hospital of Nanjing Medical University, stimuli may be a potential biomarker to distinguish the
Nanjing, 210029, China; Nanjing Brain Hospital, Medi- different states of BD. The FC ratio of VMPFC-PreCG.L
cal School of Nanjing University, Nanjing, 210093, China. connection may predict whether patients with depres-
Electronic address: [email protected]; School of Biological Sci- sive episodes subsequently develop mania.
ences & Medical Engineering, Southeast University, Nanjing,
210096, China; Child Development and Learning Science, Keywords: Bipolar disorder, Magnetoencephalography,
Key Laboratory of Ministry of Education, China. Electronic Network-based statistic, Unipolar disorder
address: [email protected]
Journal of psychiatric research (2023), Vol. 158 (36586215)
OBJECTIVE Because of the similar clinical symptoms, (0 citations)
it is difficult to distinguish unipolar disorder (UD) from
bipolar disorder (BD) in the depressive episode using
the available clinical features, especially for those who Hampered gamma oscillations induced by sad
meet the diagnostic criteria of UD, however, experience emotion underlying suicide attempt in major
the manic episode during the follow-up (tBD). depressive disorder (2023)

METHODS Magnetoencephalography recordings Dai, Zhongpeng; Zhang, Siqi; Wang, Huan; Chen, Zhilu;
during a sad expression recognition task were ob- Zhang, Wei; Hu, Xiaowen; Yao, Zhijian; Lu, Qing
tained from 81 patients (27 BD, 24 tBD, 30 UD) and 26
healthy controls (HCs). Source analysis was applied to Centre for Human Brain Health, School of Psychology, Uni-
localize 64 regions of interest in the low gamma band versity of Birmingham, Birmingham, UK; School of Biological
(30-50 Hz). Regional functional connections (FCs) were Sciences & Medical Engineering, Child Development and
constructed respectively within three time periods Learning Science, Key Laboratory of Child Development and
(early: 0-200 ms, middle: 200-400 ms, and post: 400- Learning Science, Ministry of Education, Research Center
600 ms). The network-based statistic method was used for Learning Science, Southeast University, Nanjing, China;
to explore the abnormal connection patterns in tBD Nanjing Brain Hospital, Medical School of Nanjing University,

 ontents  Index 90
C