Page 108 - MEGIN Book Of Abstracts - 2023

Madrid, Spain; Biomedical Research Networking Center in Keywords: Alzheimer’s disease, Lempel-Ziv complexity,
Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Magnetoencephalogram, Mild cognitive impairment,
Spain; Laboratory of Cognitive and Computational Neu- Source space, Subjective cognitive decline
roscience (UCM-UPM), Centre for Biomedical Technology
(CTB), Technical University of Madrid (UPM), Madrid, Spain; Clinical neurophysiology: official journal of the
Departamento de Medicina Legal, Psiquiatría y Patología, International Federation of Clinical Neurophysiology
Complutense University of Madrid, Madrid, Spain (2020), Vol. 131, No. 2 (31884374) (11 citations)

OBJECTIVE To analyse magnetoencephalogram (MEG)
signals with Lempel-Ziv Complexity (LZC) to identify What electrophysiology tells us about Alzheimer's
the regions of the brain showing changes related to disease: a window into the synchronization and
cognitive decline and Alzheimeŕs Disease (AD). connectivity of brain neurons (2020)

METHODS LZC was used to study MEG signals in the Babiloni, Claudio; Blinowska, Katarzyna; Bonanni,
source space from 99 participants (36 male, 63 female, Laura; Cichocki, Andrej; De Haan, Willem; Del Percio,
average age: 71.82 ± 4.06) in three groups (33 subjects Claudio; Dubois, Bruno; Escudero, Javier; Fernández,
per group): healthy (control) older adults, older adults Alberto; Frisoni, Giovanni; Guntekin, Bahar; Hajos,
with subjective cognitive decline (SCD), and adults Mihaly; Hampel, Harald; Ifeachor, Emmanuel; Kilborn,
with mild cognitive impairment (MCI). Analyses were Kerry; Kumar, Sanjeev; Johnsen, Kristinn; Johannsson,
performed in broadband (2-45 Hz) and in classic narrow Magnus; Jeong, Jaeseung; LeBeau, Fiona; Lizio, Roberta;
bands (theta (4-8 Hz), alpha (8-12 Hz), low beta (12- Lopes da Silva, Fernando; Maestú, Fernando; McGeown,
20 Hz), high beta (20-30 Hz), and, gamma (30-45 Hz)). William J; McKeith, Ian; Moretti, Davide Vito; Nobili,
Flavio; Olichney, John; Onofrj, Marco; Palop, Jorge J;
RESULTS LZC was significantly lower in subjects with Rowan, Michael; Stocchi, Fabrizio; Struzik, Zbigniew
MCI than in those with SCD. Moreover, subjects with M; Tanila, Heikki; Teipel, Stefan; Taylor, John Paul;
MCI had significantly lower MEG complexity than Weiergräber, Marco; Yener, Gorsev; Young-Pearse, Tracy;
controls and SCD subjects in the beta frequency band. Drinkenburg, Wilhelmus H; Randall, Fiona
Lower complexity was correlated with smaller hippo-
campal volumes. Department of Physiology and Pharmacology "Vittorio
Erspamer", Sapienza University of Rome, Rome, Italy; Hospital
CONCLUSIONS Brain complexity - measured with LZC San Raffaele Cassino, Cassino (FR), Italy. Electronic address:
- decreases in MCI patients when compared to SCD [email protected]; Faculty of Physics, University
and healthy controls. This decrease is associated with a of Warsaw and Nalecz Institute of Biocybernetics, Warsaw,
decrease in hippocampal volume, a key feature in AD Poland; Department of Neuroscience Imaging and Clinical
progression. Sciences and CESI, University G D'Annunzio of Chieti-Pescara,
Chieti, Italy; Skolkovo Institute of Science and Technology
SIGNIFICANCE This is the first study to date character- (SKOLTECH), Moscow, Russia; Systems Research Institute
ising the changes of brain activity complexity showing PAS, Warsaw, Poland; Nicolaus Copernicus University (UMK),
the specific spatial pattern of the alterations as well as Torun, Poland; Amsterdam Neuroscience, Department of
the morphological correlations throughout preclinical Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam,
stages of AD. Amsterdam, The Netherlands; Institute of Memory and
Alzheimer's Disease (IM2A), Department of Neurology,
Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, Paris,
France; Institut du Cerveau et de la Moelle épinière, ICM,
INSERM U1127, Sorbonne Université, Paris, France; School
of Engineering, Institute for Digital Communications, The

 ontents  Index 87
C