Page 107 - MEGIN Book Of Abstracts - 2023

score changes were correlated with beta activity in the toencephalography with [[18]F]AV-1451 PET scanning
sensorimotor area. These findings corroborate previ- to quantify Tau-dependent network changes. Using a
ous studies confirming NPT effects on brain activity in graph theoretical approach to brain connectivity, we
healthy participants and people at risk of dementia. quantified nodal measures of functional segregation,
Our results provide additional evidence that brains of centrality, and the efficiency of information transfer and
patients with dementia have the capacity for plasticity, tested them against levels of [[18]F]AV-1451. Higher
which may be responsible for the observed NPT effects. Tau burden in early Alzheimer's disease was associated
In dementia, NPT might lead to improvements in the with a shift away from the optimal small-world organi-
quality of life. zation and a more fragmented network in the beta and
gamma bands, whereby parieto-occipital areas were
Scientific reports (2020), Vol. 10, No. 1 (32317774) (16 disconnected from the anterior parts of the network.
citations) Similarly, higher Tau burden was associated with de-
creases in both local and global efficiency, especially in
the gamma band. The results support the translational
Tau pathology in early Alzheimer's disease is linked development of neurophysiological "signatures" of
to selective disruptions in neurophysiological Alzheimer's disease, to understand disease mecha-
network dynamics (2020) nisms in humans and facilitate experimental medicine
studies.
Kocagoncu, Ece; Quinn, Andrew; Firouzian, Azadeh;
Cooper, Elisa; Greve, Andrea; Gunn, Roger; Green, Keywords: Alzheimer's disease, Connectivity, Graph
Gary; Woolrich, Mark W; Henson, Richard N; Lovestone, theory, MEG, PET, Tau
Simon; Deep and Frequent Phenotyping study team;
Rowe, James B Neurobiology of aging (2020), Vol. 92 (32280029) (18
citations)
Department of Clinical Neurosciences, University of Cam-
bridge, Cambridge, UK; MRC Cognition and Brain Sciences
Unit, University of Cambridge, Cambridge, UK. Electronic Complexity changes in preclinical Alzheimer's
address: [email protected]; Oxford Centre for Human Brain disease: An MEG study of subjective cognitive
Activity, Wellcome Centre for Integrative Neuroimaging, decline and mild cognitive impairment (2020)
University of Oxford, Oxford, UK; Department of Psychiatry,
University of Oxford, Oxford, UK; Invicro LLC, London, UK; Shumbayawonda, Elizabeth; López-Sanz, David; Bruña,
Invicro LLC, London, UK; Department of Medicine, Imperial Ricardo; Serrano, Noelia; Fernández, Alberto; Maestú,
College London, London, UK; Department of Engineering Fernando; Abasolo, Daniel
Science, University of Oxford, Oxford, UK; Department of
Psychology, University of York, York, UK; MRC Cognition and Centre for Biomedical Engineering, Department of Mechani-
Brain Sciences Unit, University of Cambridge, Cambridge, UK; cal Engineering Sciences, Faculty of Engineering and Physical
Department of Psychiatry, University of Cambridge, Cam- Sciences, University of Surrey, Guildford GU2 7XH, UK; Labora-
bridge, UK tory of Cognitive and Computational Neuroscience (UCM-
UPM), Centre for Biomedical Technology (CTB), Technical
ABSTRACT Understanding the role of Tau protein ag- University of Madrid (UPM), Madrid, Spain; Department of
gregation in the pathogenesis of Alzheimer's disease Experimental Psychology, Complutense University of Madrid,
is critical for the development of new Tau-based Madrid, Spain. Electronic address: [email protected];
therapeutic strategies to slow or prevent dementia. Laboratory of Cognitive and Computational Neuroscience
We tested the hypothesis that Tau pathology is as- (UCM-UPM), Centre for Biomedical Technology (CTB), Techni-
sociated with functional organization of widespread cal University of Madrid (UPM), Madrid, Spain; Department of
neurophysiological networks. We used electro-magne- Experimental Psychology, Complutense University of Madrid,

 ontents  Index 86
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