Page 105 - MEGIN Book Of Abstracts - 2023

ABSTRACT This study aimed to examine whether mag- integrity of neural connections. MEG findings include
netoencephalography (MEG) is useful to detect early slowness of the oscillatory activity, accompanied by a
stage Alzheimer's disease (AD). We analyzed MEG data reduction of the alpha band power, and dysfunction of
from the early stage AD group (n = 20; 6 with mild cog- the functional networks. These findings are associated
nitive impairment due to AD and 14 with AD dementia) with the neuropathology of the disease and cognitive
and cognitively normal control group (NC, n = 27). MEG impairment. These neurophysiological biomarkers pre-
was recorded during resting eyes closed (EC) and eyes dict which patients with mild cognitive impairment will
open (EO), and the following 6 values for each of 5 develop dementia. MEG has demonstrated its utility as
bands (θ1: 4-6, θ2: 6-8, α1: 8-10, α2: 10-13, β: 13-20 Hz) a noninvasive biomarker for early detection of AD.
in the cerebral 68 regions were compared between
the groups: (1) absolute power during EC and (2) EO, Keywords: Alzheimer disease, Functional connectivity,
(3) whole cerebral normalization (WCN) power during Magnetoencephalography, Mild cognitive impairment,
EC and (4) EO, (5) difference of the absolute powers Power, Preclinical stages, Prodromal stages
between the EC and EO conditions (the EC-EO differ-
ence), and (6) WCN value of the EC-EO difference. We Neuroimaging clinics of North America (2020), Vol. 30, No.
found significant differences between the groups in the 2 (32336408) (3 citations)
WCN powers during the EO condition, and the EC-EO
differences. Using a Support Vector Machine classifier,
a discrimination accuracy of 83% was obtained and an The relationship between physical activity,
AUC in an ROC analysis was 0.91. This study demon- apolipoprotein E ε4 carriage, and brain health
strates that MEG during resting EC and EO is useful in (2020)
discriminating between early stage AD and NC.
de Frutos-Lucas, Jaisalmer; Cuesta, Pablo; López-Sanz,
Scientific reports (2020), Vol. 10, No. 1 (32499487) (3 David; Peral-Suárez, África; Cuadrado-Soto, Esther;
citations) Ramírez-Toraño, Federico; Brown, Belinda M; Serrano,
Juan M; Laws, Simon M; Rodríguez-Rojo, Inmaculada C;
Verdejo-Román, Juan; Bruña, Ricardo; Delgado-Losada,
Role of Magnetoencephalography in the Early Maria L; Barabash, Ana; López-Sobaler, Ana M; López-
Stages of Alzheimer Disease (2020) Higes, Ramón; Marcos, Alberto; Maestú, Fernando

Maestú, Fernando; Fernández, Alberto Collaborative Genomics Group, School of Medical and
Health Sciences, Edith Cowan University, Joondalup, Western
Department of Experimental Psychology, Complutense Australia, 6027, Australia. [email protected];
University of Madrid, Madrid, Spain; Centro de Tecnología Department of Industrial Engineering & IUNE, Universidad
Biomédica, Campus de Montegancedo de la UPM, Pozu- de La Laguna, 38200, San Cristobal de la Laguna, Tenerife,
elo de Alarcón, Madrid 28223, Spain. Electronic address: Spain; Department of Psychobiology and Methodology in
[email protected]; Centro de Tecnología Biomédica, Campus Behavioral Sciences, School of Education, Universidad Com-
de Montegancedo de la UPM, Pozuelo de Alarcón, Madrid plutense de Madrid, 28040, Madrid, Spain; Departamento de
28223, Spain; Department of Legal Medicine, Psychiatry and Nutricion y Ciencia de los Alimentos, Facultad de Farmacia,
Pathology, Complutense University of Madrid, Madrid, Spain Universidad Complutense de Madrid, 28040, Madrid, Spain;
Experimental Psychology Department, School of Psychology,
ABSTRACT As synaptic dysfunction is an early mani- Universidad Complutense de Madrid, 28223, Pozuelo de Alar-
festation of Alzheimer disease (AD) pathology, mag- con, Spain; Discipline of Exercise Science, College of Science,
netoencephalography (MEG) is capable of detecting Health, Engineering and Education, Murdoch University,
disruptions by assessing the synchronized oscilla- Murdoch, Western Australia, 6150, Australia; Biological and
tory activity of thousands of neurons that rely on the Health Psychology Department, School of Psychology, Uni-

 ontents  Index 84
C