Page 101 - MEGIN Book Of Abstracts - 2023

Functional decline of the precuneus Age and APOE genotype affect the relationship
associated with mild cognitive impairment: between objectively measured physical activity and
Magnetoencephalographic observations (2020) power in the alpha band, a marker of brain disease
(2020)
Yokosawa, Koichi; Kimura, Keisuke; Takase, Ryoken;
Murakami, Yui; Boasen, Jared de Frutos-Lucas, Jaisalmer; Cuesta, Pablo; Ramírez-
Toraño, Federico; Nebreda, Alberto; Cuadrado-Soto,
Faculty of Health Sciences, Hokkaido University, Sapporo, Esther; Peral-Suárez, África; Lopez-Sanz, David; Bruña,
Hokkaido, Japan; Graduate School of Health Sciences, Hok- Ricardo; Marcos-de Pedro, Silvia; Delgado-Losada,
kaido University, Sapporo, Hokkaido, Japan; Department of María Luisa; López-Sobaler, Ana María; Concepción
Occupational Therapy, Faculty of Human Science, Hokkaido Rodríguez-Rojo, Inmaculada; Barabash, Ana; Serrano
Bunkyo University, Eniwa, Hokkaido, Japan; Tech3Lab, HEC Rodriguez, Juan Manuel; Laws, Simon M; Dolado,
Montréal, Montréal, Quebec, Canada Alberto Marcos; López-Higes, Ramón; Brown, Belinda
M; Maestú, Fernando
ABSTRACT Mild Cognitive Impairment (MCI) is a border
or precursor state of dementia. To optimize implement- Laboratory of Cognitive and Computational Neuroscience
ed interventions for MCI, it is essential to clarify the (UCM-UPM), Center for Biomedical Technology, Parque
underlying neural mechanisms. However, knowledge Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223,
regarding the brain regions responsible for MCI is still Pozuelo de Alarcón, Madrid, Spain. [email protected];
limited. Here, we implemented the Montreal Cognitive Experimental Psychology Department, School of Psychol-
Assessment (MoCA) test, a screening tool for MCI, in 20 ogy, Universidad Complutense de Madrid, 28223, Pozuelo
healthy elderly participants (mean age, 67.5 years), and de Alarcon, Spain; IMDEA-Food, CEI UAM + CSIC, Madrid,
then recorded magnetoencephalograms (MEG) while 28049, Spain; Departamento de Nutricion y Ciencia de los
they performed a visual sequential memory task. In the Alimentos, Facultad de Farmacia, Universidad Complutense
task, each participant memorized the four possible di- de Madrid, 28040, Madrid, Spain; Department of Psychobiol-
rections of seven sequentially presented arrow images. ogy and Methodology in Behavioral Sciences, Universidad
Recall accuracy for beginning items of the memory se- Complutense de Madrid (UCM), Pozuelo de Alarcón, 28223,
quence was significantly positively related with MoCA Spain; Networking Research Center on Bioengineering,
score. Meanwhile, MEG revealed stronger alpha-band Biomaterials and Nanomedicine (CIBER-BBN), 28029, Madrid,
(8-13 Hz) rhythm desynchronization bilaterally in the Spain; Departamento de Especialidades Medicas y Salud
precuneus (PCu) for higher MoCA (normal) participants. Pública, Universidad Rey Juan Carlos, 28922, Alcorcon, Spain;
Most importantly, this PCu desynchronization response Physiotherapy and Nursing Faculty, University of Castilla-La
weakened in correspondence with lower MoCA score Mancha, Toledo, 45004, Spain; Facultad de Psicología, Centro
during the beginning of sequential memory encoding, Universitario Villanueva, 28034, Madrid, Spain; Biological and
a time period that should rely on working memory and Health Psychology Department, School of Psychology, Uni-
be affected by declined cognitive function. Our results versidad Autonoma de Madrid, 28049, Madrid, Spain; School
suggest that deactivation of the PCu is associated with of Pharmacy and Biomedical Sciences, Faculty of Health
early MCI, and corroborate pathophysiological findings Sciences, Curtin Health Innovation Research Institute, Curtin
based on post-mortem tissue which have implicated University, Bentley, Western Australia, 6102, Australia; Neurol-
hypoperfusion of the PCu in early stages of Alzheimer ogy Department, Hospital Clinico San Carlos and Instituto
disease. Our results indicate the possibility that cogni- de Investigación Sanitaria del Hospital Clínico San Carlos,
tive decline can be detected early and non-invasively 28040, Madrid, Spain; Discipline of Exercise Science, College
by monitoring PCu activity with electrophysiological of Science, Health, Engineering and Education, Murdoch
methods. University, Murdoch, Western Australia, 6150, Australia

PloS one (2020), Vol. 15, No. 9 (32986743) (6 citations)

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