Page 112 - MEGIN Book Of Abstracts - 2023

Nanjing, China; Department of Psychiatry, The Affiliated Brain Keywords: brain dynamics, gamma oscillations, major
Hospital of Nanjing Medical University, Nanjing, China depressive disorders, negative emotional bias, suicide
attempt
AIM Major depressive disorder (MDD) is associated
with high suicidality, especially for those with suicide Psychiatry and clinical neurosciences (2023), Vol. 77, No. 1
attempt (SA). Although impaired oscillatory activity has (36207792) (1 citation)
been previously reported in patients with SA, little is
known about precise temporal-spatial variability of its
neural dynamics. To solve this, the current study probed Association between cognitive impairments
the spectral power and network interactions underly- and aberrant dynamism of overlapping brain
ing SA in MDD. sub-networks in unmedicated major depressive
disorder: A resting-state MEG study (2023)
METHODS The present study recruited 104 subjects
including 56 subjects with MDD (30 with SA and 26 Zhong, Shuming; Chen, Nan; Lai, Shunkai; Shan,
without SA) and 48 healthy controls, who performed Yanyan; Li, Zhinan; Chen, Junhao; Luo, Aiming; Zhang,
sad expressions recognition task during magneto- Yiliang; Lv, Sihui; He, Jiali; Wang, Ying; Yao, Zhijun; Jia,
encephalography (MEG) recording. By investigating Yanbin
source-reconstructed MEG-data, brain states represent-
ing different task stages were estimated from a Hidden Department of Psychiatry, First Affiliated Hospital, Jinan Uni-
Markov model. Spectrum power and network connec- versity, Guangzhou 510630, China; School of Information Sci-
tivity were compared via Gaussian Mixture Models, and ence and Engineering, Lanzhou University, Lanzhou 730000,
fractional occupancy (FO) of states were compared via China; Medical Imaging Center, First Affiliated Hospital, Jinan
an independent F-test. University, Guangzhou 510630, China. Electronic address:
[email protected]; School of Information Science and En-
RESULTS Brain states were corresponding to various gineering, Lanzhou University, Lanzhou 730000, China. Elec-
frequencies (theta/beta/low gamma/ high gamma). tronic address: [email protected]; Department of Psychiatry,
In low gamma band (35-45 Hz), the early visual state First Affiliated Hospital, Jinan University, Guangzhou 510630,
exhibited increased activation and hyper inter-network China. Electronic address: [email protected]
connectivity between visual regions and the limbic
system, while the middle fronto-parietal state exhibited OBJECTIVE Little is known about the pathogenesis
attenuated activation and decreased intra-network underlying cognitive impairment in major depressive
connectivity within fronto-parietal regions in SA group. disorder (MDD). We aimed to explore the mechanisms
Crucially, FO values of these two states were significant- of cognitive impairments among patients with MDD by
ly correlated with the suicide risks. investigating the dynamics of overlapping brain sub-
networks.
CONCLUSIONS Suicide behavior of patients with MDD
was significantly associated with aberrant oscillations METHODS Forty unmedicated patients with MDD and
in low gamma band. Elevated oscillations in occipital 28 healthy controls (HC) were enrolled in this study.
cortices and attenuated oscillations in fronto-parietal Cognitive function was measured using the Chinese
cortices were significantly associated with SA. Manifest- versions of MATRICS Consensus Cognitive Battery
ing sadness indulging and reckless decision-making, (MCCB). All participants were scanned using a whole-
the hampered temporal characteristics could help head resting-state magnetoencephalography (MEG)
explain the neural-electric basis of SA. machine. The dynamism of neural sub-networks was
analyzed based on the detection of overlapping com-
munities in five frequency bands of oscillatory brain
signals.

 ontents  Index 91
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