Page 116 - MEGIN Book Of Abstracts - 2023

suicide-attempted patients, together with 49 matched sity of the Negev, Israel; and Department of Psychology and
health-controls. For the source-space signals, Hidden Gonda Brain Science Center, Bar-Ilan University, Israel; Baruch
Markov Model (HMM) helped to capture the sub- Ivcher School of Psychology, Interdisciplinary Center Herzliya,
second dynamic activity via a hidden sequence of finite Israel; and Child Study Center, Yale University, Connecticut,
number of states. Temporal parameters and spectral USA
activation were acquired for each state and then com-
pared between groups. Here, HMM states characterized BACKGROUND Exposure to maternal major depressive
the spatiotemporal signatures of eight networks. The disorder (MDD) bears long-term negative consequenc-
activity of suicide attempters switches more frequently es for children's well-being; to date, no research has
into the fronto-temporal network, as the time spent examined how exposure at different stages of develop-
occupancy of fronto-temporal state is increased and ment differentially affects brain functioning.
interval time is decreased compared with the non-sui-
cide patients. Moreover, these changes are significantly AIMS Utilising a unique cohort followed from birth
correlated with Nurses' Global Assessment of Suicide to preadolescence, we examined the effects of early
Risk scores. Suicide attempters also exhibit increased versus later maternal MDD on default mode network
state-wise activations in the theta band (4-8 Hz) in the (DMN) connectivity.
posterior default mode network centered on posterior
cingulate cortex, which can't be detected in the static METHOD Maternal depression was assessed at birth
spectral analysis. These alternations may disturb the and ages 6 months, 9 months, 6 years and 10 years, to
time allocations of cognitive control regulations and form three groups: children of mothers with consistent
cause inflexible decision making to SA. As the better depression from birth to 6 years of age, which resolved
sensitivity of dynamic study in reflecting SA diathesis by 10 years of age; children of mothers without depres-
than the static is validated, dynamic stability could sion; and children of mothers who were diagnosed
serve as a potential neuronal marker for SA. with MDD in late childhood. In preadolescence, we
used magnetoencephalography and focused on theta
Keywords: Dynamics, Magnetoencephalography, Major rhythms, which characterise the developing brain.
depressive disorder, Oscillations, Resting state, Suicide
RESULTS Maternal MDD was associated with disrupted
European archives of psychiatry and clinical neuroscience DMN connectivity in an exposure-specific manner. Early
(2022), Vol. 272, No. 8 (35088122) (0 citations) maternal MDD decreased child connectivity, present-
ing a profile typical of early trauma or chronic adver-
sity. In contrast, later maternal MDD was linked with
Investigating default mode network connectivity tighter connectivity, a pattern characteristic of adult
disruption in children of mothers with depression depression. Aberrant DMN connectivity was predicted
(2022) by intrusive mothering in infancy and lower mother-
child reciprocity and child empathy in late childhood,
Zeev-Wolf, Maor; Dor-Ziderman, Yair; Pratt, Maayan; highlighting the role of deficient caregiving and
Goldstein, Abraham; Feldman, Ruth compromised socio-emotional competencies in DMN
dysfunction.
Baruch Ivcher School of Psychology, Interdisciplinary Center
Herzliya, Israel; and Department of Education and Zlotowski CONCLUSIONS The findings pinpoint the distinct ef-
Center for Neuroscience, Ben Gurion University of the Negev, fects of early versus later maternal MDD on the DMN, a
Israel; Baruch Ivcher School of Psychology, Interdisciplinary core network sustaining self-related processes. Results
Center Herzliya, Israel; and Edmond J. Safra Brain Research emphasise that research on the influence of early
Center, University of Haifa, Israel; Department of Education adversity on the developing brain should consider the
and Zlotowski Center for Neuroscience, Ben Gurion Univer- developmental stage in which the adversity occured.

 ontents  Index 95
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