Page 121 - MEGIN Book Of Abstracts - 2023

Ketamine Alters Electrophysiological Responses fixed effects models examined interactions between
to Emotional Faces in Major Depressive Disorder diagnosis, stimulus valence, and drug session for be-
(2021) havioral and MEG data.

Lundin, Nancy B; Sepe-Forrest, Linnea; Gilbert, Jessica RESULTS In baseline behavioral analyses, MDD par-
R; Carver, Frederick W; Furey, Maura L; Zarate, Carlos A; ticipants exhibited higher accuracy for sad-angry
Nugent, Allison C than happy-neutral faces, and HVs responded faster
to happy-neutral than sad-angry faces. In the MEG
Section on the Neurobiology and Treatment of Mood Dis- post-infusion analyses, calcarine M100 amplitudes were
orders, Intramural Research Program, National Institute of larger in MDD than HV participants post-placebo but
Mental Health, National Institutes of Health, Bethesda, MD, became more similar post-ketamine. Finally, fusiform
USA;; Department of Psychological and Brain Sciences and M170 amplitudes were associated with antidepressant
Program in Neuroscience, Indiana University, Bloomington, response in MDD participants.
IN, USA; Department of Psychological and Brain Sciences and
Program in Neuroscience, Indiana University, Bloomington, LIMITATIONS The modest sample size and the need to
IN, USA;; Magnetoencephalography Core Facility, National collapse across responses to happy and neutral faces
Institute of Mental Health, Bethesda, MD, USA; Janssen Phar- to increase statistical power limit the generalizability of
maceuticals of Johnson and Johnson Inc., San Diego, CA, the findings.
United States; Section on the Neurobiology and Treatment
of Mood Disorders, Intramural Research Program, National CONCLUSIONS Ketamine rapidly altered emotional
Institute of Mental Health, National Institutes of Health, stimulus processing in MDD, laying the groundwork for
Bethesda, MD, USA;; Magnetoencephalography Core Facility, future investigations of biomarkers of antidepressant
National Institute of Mental Health, Bethesda, MD, USA;. treatment response.
Electronic address: [email protected]
CLINICAL TRIAL Clinicaltrials.gov, NCT#00088699.
BACKGROUND The glutamatergic modulator ketamine
rapidly reduces depressive symptoms in individuals Keywords: depression, emotional face processing, ket-
with treatment-resistant major depressive disorder amine, magnetoencephalography
(MDD). However, ketamine's effects on emotional
processing biases remain largely unknown, and Journal of affective disorders (2021), Vol. 279 (33074143)
understanding these processes may help elucidate (3 citations)
ketamine's mechanism of action.

METHODS Magnetoencephalography (MEG) was Troubled Hearts: Association Between Heart Rate
used to investigate ketamine's effects on early visual Variability and Depressive Symptoms in Healthy
responses to affective stimuli in individuals with MDD Children (2020)
(n=31) and healthy volunteers (HVs; n=24). Participants
were enrolled in a double-blind, placebo-controlled, Gleichmann, Dathan C; Solis, Isabel; Janowich,
crossover clinical trial and were assessed at baseline Jacqueline R; Wang, Yu-Ping; Calhoun, Vince D; Wilson,
and after subanesthetic-dose ketamine and placebo- Tony W; Stephen, Julia M
saline infusions. During MEG recording, participants
completed an emotional evaluation task in which they The Mind Research Network, 1101 Yale Blvd NE, Albuquerque,
indicated the sex or emotional valence (happy-neutral NM, 87106, USA; Tulane University, 6823 St. Charles Ave, New
or sad-angry) of facial stimuli. Source-localized event- Orleans, LA, 70118, USA; University of New Mexico, Albuquer-
related field (ERF) M100 and M170 amplitudes and que, NM, 87131, USA; University of Nebraska Medical Center,
latencies were extracted from regions of interest. Linear S 42nd St. & Emile St, Omaha, NE, 68198, USA; The Mind Re-

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C