Page 122 - MEGIN Book Of Abstracts - 2023

search Network, 1101 Yale Blvd NE, Albuquerque, NM, 87106, Bethesda, MD 20892, USA. Electronic address: nugenta@nih.
USA. [email protected] gov; Sir Peter Mansfield Imaging Centre, School of Physics
and Astronomy, University of Nottingham, University Park,
ABSTRACT Heart rate variability (HRV) captures the Nottingham NG7 2RD, UK
change in timing of consecutive heart beats and is
reduced in individuals with depression and anxiety. The ABSTRACT Major depressive disorder (MDD) is highly
present study investigated whether typically-develop- heterogeneous in its clinical presentation. The pres-
ing children without clinically recognized signs of de- ent exploratory study used magnetoencephalography
pression or anxiety showed a relationship between HRV (MEG) to investigate electrophysiological intrinsic
and depressive or anxiety symptoms. Children aged connectivity differences between healthy volunteers
9-14 years (N = 104) provided three minutes of cardiac and unmedicated participants with treatment-resistant
signal during eyes closed rest and eyes open rest. The MDD. The study examined canonical frequency bands
association between high frequency HRV, low frequen- from delta through gamma. In addition to group
cy HRV, root mean square of the successive differences comparisons, correlational studies were conducted to
(RMSSD), and pNN20 versus depressive symptoms (NIH determine whether connectivity was related to five
Toolbox and Child Behavior Checklist) was investigated. symptom factors: depressed mood, tension, nega-
Results partially confirm our hypothesis, with pNN20 tive cognition, suicidal thoughts, and amotivation.
positively correlated with the self-reported depres- The MDD and healthy volunteer groups did not differ
sion measure of loneliness while controlling for age, significantly at baseline when corrected across all
sex, social status, and physical activity. The association frequencies and clusters, although evidence of general-
was stronger in male participants. However, there is no ized slowing in MDD was observed. Notably, however,
consensus in the literature about which HRV measures electrophysiological connectivity was strongly related
are associated with depressive symptoms in healthy to suicidal thoughts, particularly as coupling of low fre-
children. Additional studies are needed which reliably quency power fluctuations (delta and theta) with alpha
account for variables that influence HRV to establish and beta power. This analysis revealed hub areas under-
whether certain HRV measures can be used as an early lying this symptom cluster, including left hippocampus,
marker for depression risk in children. left anterior insula, and bilateral dorsolateral prefrontal
cortex. No other symptom cluster demonstrated a rela-
Keywords: Depression, Healthy children, Heart rate vari- tionship with neurophysiological connectivity, suggest-
ability, Loneliness, RMSSD, pNN20 ing a specificity to these results as markers of suicidal
ideation.
Applied psychophysiology and biofeedback (2020), Vol.
45, No. 4 (32978742) (0 citations) Keywords: Connectivity, Frequency, Magnetoencephalog-
raphy, Major depressive disorder, Oscillation, Suicide

Multilayer MEG functional connectivity as a NeuroImage. Clinical (2020), Vol. 28 (32836087) (8
potential marker for suicidal thoughts in major citations)
depressive disorder (2020)

Nugent, Allison C; Ballard, Elizabeth D; Gilbert, Jessica R; Ketamine metabolites, clinical response, and
Tewarie, Prejaas K; Brookes, Matthew J; Zarate, Carlos A gamma power in a randomized, placebo-controlled,
crossover trial for treatment-resistant major
MEG Core Facility, National Institute of Mental Health, Na- depression (2020)
tional Institutes of Health, Bethesda, MD 20892, USA; Experi-
mental Therapeutics and Pathophysiology Branch, National Farmer, Cristan A; Gilbert, Jessica R; Moaddel, Ruin;
Institute of Mental Health, National Institutes of Health, George, Jomy; Adeojo, Lilian; Lovett, Jacqueline;

 ontents  Index 101
C