Page 117 - MEGIN Book Of Abstracts - 2023

Keywords: Depressive disorders, aetiology, childhood and healthy controls. These kinds of dysregulation
experience, imaging, social functioning could also predict the potential treatment response.

The British journal of psychiatry: the journal of mental CONCLUSION The attenuated alpha-gamma cou-
science (2022), Vol. 220, No. 3 (35049492) (2 citations) pling in dual pathways indicated increased sensitivity
to the negative emotional information and reduced
moderated effect of the amygdala, which might cause
Attenuated alpha-gamma coupling in emotional insensitivity to antidepressant treatment and could be
dual pathways with right-Amygdala predicting regarded as potential neural mechanisms for treatment
ineffective antidepressant response (2022) response prediction.

Dai, Zhongpeng; Pei, Cong; Zhang, Siqi; Tian, Shui; Keywords: alpha-gamma coupling, amygdala, antidepres-
Chen, Zhilu; Zhou, Hongliang; Lu, Qing; Yao, Zhijian sant response, dual pathways, magnetoencephalography,
negative stimuli
Key Laboratory of Child Development and Learning Science,
School of Biological Sciences & Medical Engineering, Child CNS neuroscience & therapeutics (2022), Vol. 28, No. 3
Development and Learning Science, Research Center for (34953030) (3 citations)
Learning Science, Ministry of Education, Southeast University,
Nanjing, China; Nanjing Brain Hospital, Medical School of
Nanjing University, Nanjing, China; Department of Psychiatry, Differences in verbal and spatial working memory
The Affiliated Brain Hospital of Nanjing Medical University, in patients with bipolar II and unipolar depression:
Nanjing, China an MSI study (2021)

AIMS The diversity of treatment outcomes for ma- Li, Zhinan; Chen, Junhao; Feng, Yigang; Zhong,
jor depressive disorder (MDD) remains uncertain in Shuming; Tian, Shui; Dai, Zhongpeng; Lu, Qing; Guan,
neuropathology. The current study aimed at exploring Yufang; Shan, Yanyan; Jia, Yanbin
electrophysiological biomarkers associated with treat-
ment response. Psychiatric Department, The Third Affiliated Hospital of Sun
Yat-sen University, Guangzhou, China; Psychiatric Depart-
METHODS The present study recruited 130 subjects ment, The First Affiliated Hospital of Jinan University, 613
including 100 MDD patients and 30 healthy controls. West Huangpu Avenue, Guangzhou, 510630, China; Depart-
All subjects participated in a sad expression recogni- ment of Electrophysiology, the Guangdong 999 brain Hospi-
tion task while their magnetoencephalography data tal, Guangzhou, China; Key Laboratory of Child Development
were recorded. Patients who had a reduction of at least and Learning Science, Southeast University, Nanjing, China;
50% in disorder severity at endpoint (>2 weeks) were Psychiatric Department, The First Affiliated Hospital of Jinan
considered as responders. Within-frequency power and University, 613 West Huangpu Avenue, Guangzhou, 510630,
phase-amplitude coupling were measured for the brain China. [email protected]
regions involved in the emotional visual information
processing pathways. BACKGROUND Depressive symptoms could be simi-
larly expressed in bipolar and unipolar disorder. How-
RESULTS The significant alpha-gamma decoupling ever, changes in cognition and brain networks might
from the right thalamus to the right amygdala in be quite distinct. We aimed to find out the difference in
unconscious processing and from right orbital frontal the neural mechanism of impaired working memory in
cortices to the right amygdala in conscious processing patients with bipolar and unipolar disorder.
was found in non-responders relative to responders

 ontents  Index 96
C