Page 118 - MEGIN Book Of Abstracts - 2023

METHOD According to diagnostic criteria of bipolar Hospital of Nanjing Medical University, Nanjing 210029,
II disorder of the Diagnostic and Statistical Manual China; Nanjing Brain Hospital, Medical School of Nanjing
of Mental Disorders, Fifth Edition (DSM-5) and as- University, Nanjing 210093, China; School of Biological Sci-
sessments, 13 bipolar II depression (BP II), 8 unipolar ences & Medical Engineering, Southeast University, Nanjing
depression (UD) patients and 15 healthy controls (HC) 210096, China; Child Development and Learning Science,
were recruited in the study. We used 2-back tasks Key Laboratory of Ministry of Education, China; Depart-
and magnetic source imaging (MSI) to test working ment of Biomedical Engineering, Carnegie Mellon University,
memory functions and get the brain reactions of the Pittsburgh, PA, USA; School of Biological Sciences & Medical
participants. Engineering, Southeast University, Nanjing 210096, China;
Department of Psychiatry, the Affiliated Brain Hospital of
RESULTS Compared with HC, only spatial working Nanjing Medical University, Nanjing 210029, China; Nanjing
memory tasks accuracy was significantly worse in both Brain Hospital, Medical School of Nanjing University, Nanjing
UD and BP II (p = 0.001). Pearson correlation showed 210093, China. Electronic address: zjyao@nju.edu.cn; School
that the stronger the FCs' strength of MFG-IPL and IPL- of Biological Sciences & Medical Engineering, Southeast
preSMA, the higher accuracy of SWM task within left University, Nanjing 210096, China; Child Development and
FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, Learning Science, Key Laboratory of Ministry of Education,
p = 0.031). However, the FC strength of IFG-IPL was neg- China. Electronic address: luq@seu.edu.cn
atively correlated with the accuracy of SWM task within
left FPN in patients with BP II (r = - 0.591, p = 0.033). BACKGROUND Precise suicide risk evaluation strug-
gled in Major depressive disorder (MDD), especially for
CONCLUSIONS Our study showed that the spatial patients with only suicidal-ideation (SI) but without
working memory of patients with whether UD or BP suicide attempt (SA). MDD patients have deficits in
II was impaired. The patterns of FCs within these two negative emotion processing, which is associated with
groups of patients were different when performing the generation of SI and SA. Given the critical role of
working memory tasks. gamma oscillations in negative emotion processing, we
hypothesize that the transition from SI to SA in MDD
Keywords: Depression, Frontoparietal network, Magneto- could be characterized by abnormal gamma interac-
encephalography, Working memory tions.

BMC psychiatry (2021), Vol. 21, No. 1 (34781922) (2 METHODS We recruited 162 participants contain-
citations) ing 106 MDD patients and 56 healthy controls (HCs).
Participants performed facial recognition tasks while
magnetoencephalography data were recorded. Time-
Disrupted fronto-parietal network and default- frequency-representation (TFR) analysis was conducted
mode network gamma interactions distinguishing to identify the dominant spectra differences between
suicidal ideation and suicide attempt in depression MDD and HCs, and then source analysis was applied to
(2022) localize the region of interests. Furthermore, frequency-
specific functional connectivity network were con-
Dai, Zhongpeng; Shao, Junneng; Zhou, Hongliang; structed and a semi-supervised clustering algorithm
Chen, Zhilu; Zhang, Siqi; Wang, Huan; Jiang, Haiteng; was utilized to predict potential suicide risk.
Yao, Zhijian; Lu, Qing
RESULTS Gamma (50-70 Hz) power was found signifi-
School of Biological Sciences & Medical Engineering, South- cantly increased in MDD, mainly residing in regions
east University, Nanjing 210096, China; Child Development from fronto-parietal-control-network (FPN), visual-net-
and Learning Science, Key Laboratory of Ministry of Educa- work (VN), default-mode-network (DMN) and salience-
tion, China; Department of Psychiatry, the Affiliated Brain network (SN). Based on impaired gamma functional

 ontents  Index 97
C