Page 115 - MEGIN Book Of Abstracts - 2023

Magnetoencephalography biomarkers of suicide LIMITATIONS Limitations include a small sample size of
attempt history and antidepressant response to attempters.
ketamine in treatment-resistant major depression
(2022) CONCLUSIONS The findings highlight key differ-
ences in band-limited power between attempters and
Gilbert, Jessica R; Gerner, Jessica L; Burton, Courtney R; non-attempters and reinforce previous findings that
Nugent, Allison C; Zarate, Carlos A; Ballard, Elizabeth D ketamine has distinct response properties in patients
with a suicide history.
Experimental Therapeutics and Pathophysiology Branch,
National Institute of Mental Health, National Institutes of Keywords: Ketamine, Magnetoencephalography, Suicidal
Health, Bethesda, MD, USA. Electronic address: jessica.gil- ideation, Suicide attempt, Treatment-resistant depression
[email protected]; MEG Core Facility, National Institute of Mental
Health, National Institutes of Health, Bethesda, MD, USA Journal of affective disorders (2022), Vol. 312 (35728680)
(0 citations)
BACKGROUND This study examined magnetoencepha-
lographic (MEG) correlates of suicidal ideation (SI) and
suicide attempt history in patients with treatment-resis- Spontaneous transient states of fronto-temporal
tant major depression (TRD) at baseline and following and default-mode networks altered by suicide
subanesthetic-dose ketamine infusion. attempt in major depressive disorder (2022)

METHODS Twenty-nine drug-free TRD patients (12 sui- Zhang, Siqi; Litvak, Vladimir; Tian, Shui; Dai, Zhongpeng;
cide attempters/17 non-attempters) participated in a Tang, Hao; Wang, Xinyi; Yao, Zhijian; Lu, Qing
crossover randomized trial of ketamine. MEG data were
collected during an attentional dot probe task with Key Laboratory of Child Development and Learning Sci-
emotional face stimuli at baseline and several hours ence of Ministry of Education, School of Biological Sciences
post-ketamine infusion. Synthetic aperture magne- & Medical Engineering, Southeast University, No. 2 Sipailou,
tometry was used to project source power in the theta, Nanjing, 210096, Jiangsu, China; Wellcome Centre for Hu-
alpha, beta, and gamma frequencies for angry-neutral, man Neuroimaging, UCL Institute of Neurology, London, UK;
happy-neutral, and neutral-neutral face pairings during Department of Psychiatry, the Affiliated Brain Hospital of
a one-second peristimulus period. Mixed models were Nanjing Medical University, Nanjing, China; Nanjing Brain
used to test for clinical, behavioral, and electrophysi- Hospital, Medical School of Nanjing University, Nanjing,
ological effects of group, emotion, session, and SI score. China; Key Laboratory of Child Development and Learning
Science of Ministry of Education, School of Biological Sciences
RESULTS Ketamine significantly reduced SI and depres- & Medical Engineering, Southeast University, No. 2 Sipailou,
sion across the sample. Post-ketamine, attempters had Nanjing, 210096, Jiangsu, China. [email protected]
improved accuracy and non-attempters had reduced
accuracy on the task. SI was positively associated with ABSTRACT Major depressive disorder (MDD) is associ-
gamma power in regions of the frontal and parietal ated with increased suicidality, and it's still challeng-
cortices across groups. In an extended amygdala-hip- ing to identify suicide in clinical practice. Although
pocampal region, attempters differed significantly in suicide attempt (SA) is the most relevant precursor
their emotional reactivity to angry versus happy faces with multiple functional abnormalities reported from
as indexed by theta power differences, irrespective neuroimaging studies, little is known about how the
of drug. Ketamine significantly reduced the associa- spontaneous transient activated patterns organize and
tion between alpha power and SI for angry compared coordinate brain networks underlying SA. Thus, we ob-
with happy faces in a fronto-insular/anterior cingulate tained resting-state magnetoencephalography data for
region important for regulating sensory attentiveness. two MDD subgroups of 44 non-suicide patients and 34

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