Page 114 - MEGIN Book Of Abstracts - 2023

and the multivariate transfer entropy of patients with cially for patients with suicide attempt (SA). Evidence
depression and healthy controls under different EEG indicated that SA may be strongly associated with
signal frequency bands is calculated. Finally, the signifi- inhibitory control deficits. We hypothesized that the
cant difference between the two groups of experimen- inhibition function deficits of patient with SA might be
tal samples is verified by the results of independent underpinned by abnormal neuronal oscillations.
sample t-test. The experimental results show that for
the same combination of brain channels, the multivari- METHODS Our study recruited 111 subjects includ-
ate transfer entropy in the depression group is gener- ing 74 patients and 37 controls, who performed a GO/
ally lower than that in the healthy control group, and NOGO task during magnetoencephalography record-
the difference is the best in γ frequency band and the ing. Time-frequency-representations and phase-am-
largest in the frontal region. plitude-coupling were measured for the brain circuits
involved in the inhibitory function. Phase-slope-index-
Computational intelligence and neuroscience (2022), Vol. es were calculated between regions to determine the
2022 (35909866) (0 citations) direction of power flow.

RESULTS Significant increased reaction time and de-
Alpha-beta decoupling relevant to inhibition creased judgment accuracy were observed in SA group.
deficits leads to suicide attempt in major depressive During the perception stage of GO task (approximately
disorder (2022) 125 ms), SA group manifested elevated alpha power in
ventral prefrontal cortex (VPFC) and attenuated beta
Dai, Zhongpeng; Zhou, Hongliang; Zhang, Wei; Tang, power in dorsal anterior cingulate (dACC) compared
Hao; Wang, Ting; Chen, Zhilu; Yao, Zhijian; Lu, Qing with other groups (p < 0.01). In the processing stage of
NOGO task (approximately 300 ms), they showed de-
School of Biological Sciences & Medical Engineering, Child creased beta power in VPFC and increased alpha power
Development and Learning Science, Key Laboratory of Child in dACC (p < 0.01). Alpha-beta decoupling during both
Development and Learning Science, Ministry of Education, tasks was observed in SA group. Furthermore, the
Research Center for Learning Science, Southeast University, decoupling from VPFC to dACC under NOGO tasks was
Nanjing 210096, China; Nanjing Brain Hospital, Medical significantly correlated with suicide risk level.
School of Nanjing University, Nanjing 210093, China; School
of Biological Sciences & Medical Engineering, Child Develop- LIMITATIONS The number of participants was relatively
ment and Learning Science, Key Laboratory of Child Develop- small, and psychological elements were not involved in
ment and Learning Science, Ministry of Education, Research current study.
Center for Learning Science, Southeast University, Nanjing
210096, China; Department of Psychiatry, the Affiliated Brain CONCLUSION Dysregulated oscillatory activities of
Hospital of Nanjing Medical University, Nanjing 210029, dACC and VPFC suggested deficits in execution and
China; Nanjing Brain Hospital, Medical School of Nanjing inhibition functions triggering high suicide risks. The
University, Nanjing 210093, China. Electronic address: alpha-beta decoupling from VPFC to dACC could be
[email protected]; School of Biological Sciences & Medi- served as a neuro-electrophysiological biomarker for
cal Engineering, Child Development and Learning Science, identifying potential suicide risk.
Key Laboratory of Child Development and Learning Science,
Ministry of Education, Research Center for Learning Science, Keywords: Alpha-beta coupling, GO/NOGO task, Inhibi-
Southeast University, Nanjing 210096, China. Electronic ad- tory function, Suicide attempt
dress: [email protected]
Journal of affective disorders (2022), Vol. 314 (35820473)
BACKGROUND One devastating outcome of major (1 citation)
depressive disorder (MDD) is high suicidality, espe-

 ontents  Index 93
C