Page 125 - MEGIN Book Of Abstracts - 2023

burgh, Pittsburgh, PA; Department of Psychiatry, University of Keywords: ECT, depression, late life, neural marker, theta
Pittsburgh, Pittsburgh, PA; Medical Scientist Training Program, cordance
Northwestern University, Chicago, IL; Program in Neural Com-
putation, Center for the Neural Basis of Cognition, Carnegie International journal of geriatric psychiatry (2020), Vol. 35,
Mellon University and University of Pittsburgh, Pittsburgh, PA No. 2 (31617234) (5 citations)

OBJECTIVES More than half of patients with major
depression who do not respond to initial antidepres- Caudothalamic dysfunction in drug-free suicidally
sants become treatment resistant (TRD), and while depressed patients: an MEG study (2020)
electroconvulsive therapy (ECT) is effective, it involves
anesthesia and other medical risks that are of concern Chattun, Mohammad Ridwan; Zhang, Siqi; Chen, Yu;
in geriatric patients. Past studies have suggested that Wang, Qiang; Amdanee, Nousayhah; Tian, Shui; Lu,
theta cordance (TC), a correlate of cerebral metabolism Qing; Yao, Zhijian
measured by electroencephalography, could guide
treatment decisions related to patient selection and Department of Psychiatry, The Affiliated Brain Hospital
engagement of the therapeutic target. of Nanjing Medical University, No. 264 Guangzhou Road,
Nanjing, 210029, China; Key Laboratory of Child Develop-
METHODS/DESIGN Eight patients with late-life treat- ment and Learning Science, Southeast University, Nanjing,
ment resistant depression (LL-TRD) underwent mag- 210096, China; Medical School of Nanjing University, Nanjing
netoencephalography (MEG) at baseline and following Brain Hospital, 22 Hankou Road, Nanjing, 210093, China;
seven sessions of ECT. We tested whether the mean Department of Geriatrics, Jiangsu Province Hospital Affili-
and regional frontal cortex TC were able to differentiate ated to Nanjing Medical University, Nanjing, 210029, China;
early responders from nonresponders. Key Laboratory of Child Development and Learning Science,
Southeast University, Nanjing, 210096, China. [email protected].
RESULTS Five patients whose depression severity de- cn; Medical School of Nanjing University, Nanjing Brain
creased by >30% after seven sessions were considered Hospital, 22 Hankou Road, Nanjing, 210093, China. zjyao@
early responders. We found no baseline differences in njmu.edu.cn
mean frontal TC between early responders compared
with nonresponders, but early responders exhibited ABSTRACT Major depressive disorder (MDD), char-
a significant increase in TC following ECT. Further, acterized by low mood or anhedonia, is commonly
we found that compared with nonresponders, early associated with a greater suicidal susceptibility. There
responders exhibited a greater change in TC specifically are numerous suicide-related findings pertaining to
within the right prefrontal cortex. the dorsolateral prefrontal cortex (DLPFC), caudate
nucleus and thalamus, which form a cortico-striato-
CONCLUSIONS These results support the hypothesis thalamo-cortical (CSTC) circuit responsible for execu-
that increases in frontal TC are associated with antide- tive function and working memory. An aberrant CSTC
pressant response. We expand on previous findings circuitry is hypothesized to be implicated in depressed
by showing that this change is specific to the right patients with a high suicidal risk. 27 MDD patients were
prefrontal cortex. Validation of this neural marker could assessed with the Nurses Global Assessment of Suicide
contribute to improved ECT outcomes, by informing Risk (NGASR), following which 14 patients were clas-
early clinical decisions about the acute efficacy of this sified into a high suicide risk group (NGASR ≥ 12) and
treatment. 13 patients were assigned to a low suicide risk group
(NGASR < 6). All 27 patients were enrolled with 25
healthy controls for resting-state magnetoencephalog-
raphy (MEG). Cross-frequency coupling (CFC) measured
the phase of alpha-band (8-13 Hz) as it modulated to

 ontents  Index 104
C