Page 126 - MEGIN Book Of Abstracts - 2023

cortical gamma-band (30-48 Hz). There was a sig- being replicated on a larger scale, and hence validates
nificantly lower alpha-to-gamma phase-amplitude caudothalamic dysfunction as a reliable neuroimaging
coupling (PAC) between the right caudate and left biomarker for suicide in depression.
thalamus in high-risk suicide group compared to both
the low-risk suicide group and healthy controls. The Keywords: Cortico-striato-thalamo-cortical (CSTC) circuit,
presence of a weaker coupling between the right cau- Cross-frequency coupling (CFC), Magnetoencephalog-
date and left thalamus is indicative of a caudothalamic raphy (MEG), Major depressive disorder (MDD), Nurses
abnormality in suicidally depressed patients. This im- global assessment of suicide risk (NGASR)
plies that a disruption of CSTC loop could result in ex-
ecutive dysfunction and working memory impairment, European archives of psychiatry and clinical neuroscience
leading to an increased suicidal risk in MDD patients. In (2020), Vol. 270, No. 2 (30552507) (13 citations)
the future, this preliminary study has the possibility of

 ontents  Index 105
C