Page 89 - MEGIN Book Of Abstracts - 2023

versus CU classification with the area under the ROC Results: We found a frontal cluster, involving anterior
curve of 0.90. This study demonstrated that MEG during cingulate and the medial frontal lobe, where women
the optic flow task can be useful in discriminating AD- showed higher FC values than men. Involved connec-
MCI from CU. tions included the following: (1) medial parietal areas,
such as posterior cingulate cortices and precunei; (2)
PloS one (2021), Vol. 16, No. 11 (34739526) (1 citation) right insula; and (3) medium cingulate and paracin-
gulate cortices. Moreover, these differences persisted
when considering only cognitively intact individuals,
Sex Differences in Magnetoencephalography- but not when considering only cognitively impaired
Identified Functional Connectivity in the Human individuals. Discussion: Increased anteroposterior FC
Connectome Project Connectomics of Brain Aging has been identified as a biomarker for increased risk of
and Dementia Cohort (2022) developing cognitive impairment or dementia. In our
study, cognitively intact women showed higher levels
Bruña, Ricardo; Maestú, Fernando; López-Sanz, David; of FC than their male counterparts. This result suggests
Bagic, Anto; Cohen, Ann D; Chang, Yue-Fang; Cheng, Yu; that neurodegenerative processes could be taking
Doman, Jack; Huppert, Ted; Kim, Tae; Roush, Rebecca E; place in these women, but the changes are undetected
Snitz, Beth E; Becker, James T by current diagnosis tools. FC, as measured here, might
be valuable for early identification of this neurodegen-
Networking Research Center on Bioengineering, Biomaterials eration.
and Nanomedicine (CIBER-BBN), Madrid, Spain; Depart-
ment of Psychobiology, Universidad Complutense de Madrid, Keywords: functional connectivity, magnetoencephalog-
Madrid, Spain; Department of Statistics, The University of raphy, sex as a biological variable
Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of
Neurosurgery, The University of Pittsburgh, Pittsburgh, Penn- Brain connectivity (2022), Vol. 12, No. 6 (34726478) (1
sylvania, USA; Department of Biostatistics, The University of citation)
Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of
Electrical Engineering, The University of Pittsburgh, Pitts-
burgh, Pennsylvania, USA; Department of Radiology, The Uni- Somatosensory dysfunction is masked by variable
versity of Pittsburgh, Pittsburgh, Pennsylvania, USA; Depart- cognitive deficits across patients on the Alzheimer's
ment of Psychiatry, The University of Pittsburgh, Pittsburgh, disease spectrum (2021)
Pennsylvania, USA; Department of Psychology, The University
of Pittsburgh, Pittsburgh, Pennsylvania, USA Wiesman, Alex I; Mundorf, Victoria M; Casagrande,
Chloe C; Wolfson, Sara L; Johnson, Craig M; May, Pamela
ABSTRACT Introduction: The human brain shows mod- E; Murman, Daniel L; Wilson, Tony W
est traits of sexual dimorphism, with the female brain,
on average, 10% smaller than the male brain. These McConnell Brain Imaging Centre, Montreal Neurological
differences do not imply a lowered cognitive perfor- Institute, McGill University, 845 Sherbrooke St W, Montreal,
mance, but suggest a more optimal brain organization QC H3A 0G4, Canada; Department of Neurological Sciences,
in women. Here we evaluate the patterns of functional University of Nebraska Medical Center (UNMC), Omaha, NE,
connectivity (FC) in women and men from the Connec- USA. Electronic address: [email protected];
tomics of Brain Aging and Dementia sample. Methods: Center for Brain, Biology, and Behavior, University of Nebraska
We used phase locking values to calculate FC from the - Lincoln, Lincoln, NE, USA; Institute for Human Neuroscience,
magnetoencephalography time series in a sample of Boys Town National Research Hospital, Boys Town, NE, USA;
138 old adults (87 females and 51 males). We compared Geriatrics Medicine Clinic, UNMC, Omaha, NE, USA; Depart-
the FC patterns between sexes, with the intention of ment of Radiology, UNMC, Omaha, NE, USA; Department of
detecting regions with different levels of connectivity. Neurological Sciences, University of Nebraska Medical Center

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