Page 276 - MEGIN Book Of Abstracts - 2023

trauma scripts PTSD patients showed increases in high- PTSD and other trauma-related outcomes based on
gamma band power in visual areas, increased frontal functional connectivity using magnetoencepha-
and temporal theta as well as prefrontal alpha and lography (MEG). A total of 121 U.S. women veterans
medial temporal beta power relative to neutral scripts. completed diagnostic interviews and underwent a
task-free MEG scan from which SNI was computed.
CONCLUSIONS Results suggest that when recollect- Linear discriminant analysis was used to classify PTSD
ing and imagining traumatic memories PTSD patients and control groups according to SNI. That discriminant
attempt to engage control or inhibition mechanisms. function was then used to classify each individual in the
However, these are either not successfully recruited or partial recovery and full recovery diagnostic groups as
inefficient leading to heightened responses and recol- PTSD or control. All individuals were classified correctly
lection. (100% accuracy) according to their SNI in their PTSD
and control groups. Seventy-seven percent of the full
SIGNIFICANCE Investigating the oscillatory neural dy- recovery group and 69% of the partial recovery group
namics of PTSD patients can help us better understand were classified as control. Individual staging in PTSD
the processes underlying trauma re-experiencing. recovery was captured by the Mahalanobis D[2] dis-
tances from the center of the control and PTSD centroid
Keywords: Imagery, Magnetoencephalography, Oscilla- clusters. These findings provide compelling evidence
tory brain activity, Post traumatic stress disorder supporting the utility of task-free SNI as a biomarker of
PTSD and related outcomes in women veterans.
Clinical neurophysiology: official journal of the
International Federation of Clinical Neurophysiology Keywords: Biomarker, Classification, Magnetoencephalog-
(2022), Vol. 139 (35537254) (0 citations) raphy, Posttraumatic stress disorder, Recovery, Veterans

Experimental brain research (2022), Vol. 240, No. 4
Classification of posttraumatic stress disorder (35133447) (2 citations)
and related outcomes in women veterans using
magnetoencephalography (2022)
Alterations in the Topology of Functional
James, Lisa M; Leuthold, Arthur F; Georgopoulos, Connectomes Are Associated with Post-Traumatic
Apostolos P Stress Disorder and Blast-Related Mild Traumatic
Brain Injury in Combat Veterans (2021)
Center for Cognitive Sciences, University of Minnesota,
Minneapolis, MN, USA. [email protected]; Department of Rowland, Jared A; Stapleton-Kotloski, Jennifer R;
Neuroscience, University of Minnesota Medical School, Min- Martindale, Sarah L; Rogers, Emily E; Ord, Anna S;
neapolis, MN, USA; Department of Neurology, University of Godwin, Dwayne W; Taber, Katherine H
Minnesota, Minneapolis, MN, USA
Department of Neurobiology and Anatomy, Wake Forest
ABSTRACT Women veterans represent a unique popu- School of Medicine, Winston-Salem, North Carolina, USA;
lation whose experiences and neurobiology differ from Department of Neurology, Wake Forest School of Medicine,
that of their male counterparts. Thus, while previous Winston-Salem, North Carolina, USA; Department of Physiol-
research has demonstrated the utility of synchronous ogy and Pharmacology, Wake Forest School of Medicine,
neural interactions (SNI) as a biomarker of posttrau- Winston-Salem, North Carolina, USA; Division of Biomedi-
matic stress disorder (PTSD) in male veterans, the utility cal Sciences, Edward Via College of Osteopathic Medicine,
of SNI as a biomarker of PTSD in women veterans is Blacksburg, Virginia, USA
unclear. Here we extend that line of research to evalu-
ate classification of women veterans with and without

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C