Page 272 - MEGIN Book Of Abstracts - 2023

Institute, Krembil Research Institute, University Health Net- Keywords: Chronic pain, Dynamic functional coupling,
work, M5T2S8, Toronto, Canada; Institute of Medical Science, Functional connectivity, Magnetoencephalography, Oscil-
Faculty of Medicine, University of Toronto, M5S1A8, Toronto, lations
Canada; Division of Neurology, Department of Medicine, St.
Michael's Hospital, M5B1W8, Toronto, Canada; Department NeuroImage. Clinical (2020), Vol. 26 (32143136) (15
of Medical Imaging, University of Toronto, M5T1W7, Toronto, citations)
Canada; Neurosciences & Mental Health Program, The Hos-
pital for Sick Children Research Institute, M5G0A4, Toronto,
Canada; Division of Brain, Imaging and Behaviour, Krembil Noninvasive muscle activity imaging using
Brain Institute, Krembil Research Institute, University Health magnetography (2020)
Network, M5T2S8, Toronto, Canada; Institute of Medical
Science, Faculty of Medicine, University of Toronto, M5S1A8, Llinás, Rodolfo R; Ustinin, Mikhail; Rykunov, Stanislav;
Toronto, Canada; Department of Surgery, University of Walton, Kerry D; Rabello, Guilherme M; Garcia, John;
Toronto, M5T1P5, Toronto, Canada. Electronic address: karen. Boyko, Anna; Sychev, Vyacheslav
[email protected]
Department of Neuroscience and Physiology, Center for Neu-
ABSTRACT Sensory perceptions are coded by complex romagnetism, New York University School of Medicine, New
neural dynamics of regional communication in the York, New York, 10016; [email protected]; Keldysh
brain. Thus, sensory abnormalities such as chronic pain Institute of Applied Mathematics, Russian Academy of Sci-
may occur when neural dynamics go awry. Previous ences, Moscow, 125047 Russia
studies of cross-network dynamic functional connectiv-
ity in chronic pain identified abnormalities but were ABSTRACT A spectroscopic paradigm has been
based on functional MRI which only captures slow tem- developed that allows the magnetic field emissions
poral features. Here we conducted a magnetoencepha- generated by the electrical activity in the human body
lography (MEG) study to investigate fine temporal to be imaged in real time. The growing significance of
dynamics of aberrant cross-regional and cross-network imaging modalities in biology is evident by the almost
communication of the dynamic pain connectome in exponential increase of their use in research, from the
patients with chronic pain. We also introduced a novel molecular to the ecological level. The method of analy-
measure, dynamic functional coupling, to quantify sis described here allows totally noninvasive imaging
the variability of brain communication. The study was of muscular activity (heart, somatic musculature). Such
performed in 33 people who had chronic pain associ- imaging can be obtained without additional method-
ated with multiple sclerosis and 30 healthy controls. We ological steps such as the use of contrast media.
found that patients with chronic pain exhibited abnor-
malities in cross-network functional coupling across Keywords: magnetocardiography, magnetoencephalog-
multiple frequency bands (theta, alpha, beta, gamma), raphy, magnetomyograph, precise frequency-pattern
between the salience network and 3 other networks: analysis
the ascending nociceptive pathway, descending anti-
nociceptive pathway, and the default mode network. Proceedings of the National Academy of Sciences of the
However, these cross-network abnormalities involved United States of America (2020), Vol. 117, No. 9 (32071237)
different frequency bands in patients with neuropathic (5 citations)
versus non-neuropathic chronic pain. Furthermore,
cross-network abnormalities were linked to pain sever-
ity and pain interference. Our findings implicate broad-
band cross-network abnormalities as hallmark features
of chronic pain in multiple sclerosis.

 ontents  Index 251
C