Page 267 - MEGIN Book Of Abstracts - 2023

data sets, BIPAC proved advantageous with regard to Taipei Veterans General Hospital, Taipei, Taiwan. sjwang@
estimation accuracy in source localization, orientation, vghtpe.gov.tw
and coupling strength. BIPAC was also applied to the
analysis of magnetoencephalographic signals recorded BACKGROUND Pain sensitivity may determine the risk,
from women with primary dysmenorrhea in an implicit severity, prognosis, and efficacy of treatment of clinical
emotional prosody experiment. In response to negative pain. Magnetic resonance imaging studies have linked
emotional prosody, auditory areas revealed strong PAC thermal pain sensitivity to changes in brain structure.
with the ventral auditory stream and occipitoparietal However, the neural correlates of mechanical pain
areas in the theta-gamma and alpha-gamma bands, sensitivity remain to be clarified through investigation
which may respectively indicate the recruitment of of direct neural activities on the resting-state cortical
auditory sensory memory and attention reorientation. oscillation and synchrony.
Moreover, patients with more severe pain experience
appeared to have stronger coupling between audi- METHODS We recorded the resting-state magnetoen-
tory areas and temporoparietal regions.Significance. cephalographic (MEG) activities of 27 healthy individu-
Our findings indicate that the implicit processing of als and 30 patients with episodic migraine (EM) and
emotional prosody is altered by menstrual pain experi- analyzed the source-based oscillatory powers and
ence. The proposed BIPAC is feasible and applicable to functional connectivity at 2 to 59 Hz in pain-related
imaging inter-regional connectivity based on cross- cortical regions, which are the bilateral anterior cingu-
frequency coupling estimates. The experimental results late cortex (ACC), medial orbitofrontal (MOF) cortex,
also demonstrate that BIPAC is capable of revealing au- lateral orbitofrontal (LOF) cortex, insula cortex, primary
tonomous brain processing and neurodynamics, which somatosensory cortex (SI), primary motor cortex (MI),
are more subtle than active and attended task-driven and posterior cingulate cortex (PCC). The mechanical
processing. punctate pain threshold (MPPT) was obtained at the
supraorbital area (the first branch of the trigeminal
Keywords: beamformer, cross-frequency coupling (CFC), nerve dermatome, V1) and the forearm (the first tho-
emotional prosody, magnetoencephalography (MEG), racic nerve dermatome, T1) and further correlated with
neural communication, phase-amplitude coupling (PAC), MEG measures.
primary dysmenorrhea (PDM)
RESULTS The MPPT is inversely correlated with the
Journal of neural engineering (2021), Vol. 18, No. 4 resting-state relative powers of gamma oscillation in
(33691295) (1 citation) healthy individuals (all corrected P < 0.05). Specifically,
inverse correlation was noted between the MPPT at V1
and gamma powers in the bilateral insula (r = - 0.592
Individual pain sensitivity is associated with [left] and - 0.529 [right]), PCC (r = - 0.619 and - 0.541) and
resting-state cortical activities in healthy MI (r = - 0.497 and - 0.549) and between the MPPT at T1
individuals but not in patients with migraine: a and powers in the left PCC (r = - 0.561) and bilateral MI
magnetoencephalography study (2020) (r = - 0.509 and - 0.520). Furthermore, resting-state func-
tional connectivity at the delta to beta bands, espe-
Hsiao, Fu-Jung; Chen, Wei-Ta; Liu, Hung-Yu; Wang, Yen- cially between frontal (MOF, ACC, LOF, and MI), parietal
Feng; Chen, Shih-Pin; Lai, Kuan-Lin; Pan, Li-Ling Hope; (PCC), and sensorimotor (bilateral SI and MI) regions,
Wang, Shuu-Jiun showed a positive correlation with the MPPT at V1 and
T1 (all corrected P < 0.05). By contrast, in patients with
Brain Research Center, National Yang-Ming University, Taipei, EM, the MPPT was not associated with resting-state
Taiwan. [email protected]; Department of Neurology, cortical activities.
Neurological Institute, Taipei Veterans General Hospital, Tai-
pei, Taiwan; Department of Neurology, Neurological Institute,

 ontents  Index 246
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