Page 262 - MEGIN Book Of Abstracts - 2023

variety in study designs, stimulation paradigms, and functional magnetic resonance imaging, electroen-
spectral features studied. Paresthesia-free paradigms cephalography, and magnetoencephalography in the
have been compared with tonic stimulation in multiple context of PLP. These imaging modalities have distinct
studies. These studies suggest modulation of medial, mechanisms, implications, applications, and limitations.
lateral, and descending pathways for paresthesia-free Diffusion tensor imaging can outline structural changes
stimulation, whereas tonic stimulation predominantly and has surgical applications. Functional magnetic
modulates lateral and descending pathways. Moreover, resonance imaging captures functional changes with
multiple studies have reported an increased alpha peak spatial resolution and has therapeutic applications.
frequency, increased alpha power, and/or decreased Electroencephalography and magnetoencephalog-
theta power when SCS was compared with baseline, raphy can identify functional changes with a strong
indicating modulation of thalamocortical pathways. temporal resolution. Each imaging technique provides
Further studies with well-defined groups of respond- a unique perspective and they can be used in concert
ers and nonresponders to SCS are recommended to to reveal the true nature of PLP. Furthermore, research-
independently study the cortical effects of pain relief ers can utilize the respective strengths of each neu-
and SCS. roimaging technique to support the development of
innovative therapies. PLP exemplifies how neuroimag-
Keywords: Chronic pain, Spinal cord stimulation (SCS), ing and clinical management are intricately connected.
cortical activity, electroencephalography (EEG), magneto- This review can assist clinicians and researchers seeking
encephalography (MEG) a foundation for applications and understanding the
limitations of neuroimaging techniques in the context
Neuromodulation: journal of the International of PLP.
Neuromodulation Society (2023), Vol. 26, No. 1 (35551867)
(0 citations) Keywords: DTI, EEG, MEG, fMRI, phantom limb pain

Brain and behavior (2022), Vol. 12, No. 3 (35218308) (1
Unveiling the phantom: What neuroimaging has citation)
taught us about phantom limb pain (2022)

Browne, Jonathan D; Fraiser, Ryan; Cai, Yi; Leung, Dillon; Complexity Assessment of Chronic Pain in Elderly
Leung, Albert; Vaninetti, Michael Knee Osteoarthritis Based on Neuroimaging
Recognition Techniques (2021)
School of Medicine, California University of Science and
Medicine, Colton, California, USA; Center for Pain Medicine, Wu, Xuemin; Liu, Jingjing; Liu, Min; Wu, Tao
University of California San Diego, La Jolla, California, USA;
College of Letters and Science, University of California Berke- Community Health Station, China University of Mining and
ley, Berkeley, California, USA Technology-Beijing, Beijing 100083, China; Beijing Institute
of Geriatrics, Xuanwu Hospital, Capital Medical University,
ABSTRACT Phantom limb pain (PLP) is a complicated Beijing 100053, China
condition with diverse clinical challenges. It consists of
pain perception of a previously amputated limb. The ABSTRACT The chronic pain of knee osteoarthritis in
exact pain mechanism is disputed and includes mecha- the elderly is investigated in detail in this paper, as well
nisms involving cerebral, peripheral, and spinal origins. as the complexity of chronic pain utilising neuroimag-
Such controversy limits researchers' and clinicians' abil- ing recognition techniques. Chronic pain in knee osteo-
ity to develop consistent therapeutics or management. arthritis (KOA) has a major effect on patients' quality of
Neuroimaging is an essential tool that can address this life and functional activities; therefore, understanding
problem. This review explores diffusion tensor imaging, the causes of KOA pain and the analgesic advantages of

 ontents  Index 241
C