Page 266 - MEGIN Book Of Abstracts - 2023

How expectations of pain elicited by consciously tion and may shed light on enhancing clinical care by
and unconsciously perceived cues unfold over time demonstrating the impact of expectation cues.
(2021)
Keywords: Conditioning, Conscious and unconscious,
Tu, Yiheng; Pantazis, Dimitrios; Wilson, Georgia; Khan, Expectation of pain, Machine learning, Neural dynamics,
Sheraz; Ahlfors, Seppo; Kong, Jian Temporal decoding, Temporal generalization

Department of Psychiatry, Massachusetts General Hospital NeuroImage (2021), Vol. 235 (33762214) (2 citations)
and Harvard Medical School, Charlestown, MA, USA; Athi-
noula A. Martinos Center for Biomedical Imaging, Massachu-
setts General Hospital and Harvard Medical School, Charles- A novel beamformer-based imaging of phase-
town, MA, USA; Department of Brain and Cognitive Sciences, amplitude coupling (BIPAC) unveiling the inter-
Massachusetts Institute of Technology, Cambridge, MA, USA; regional connectivity of emotional prosody
McGovern Institute of Brain Research, Massachusetts Institute processing in women with primary dysmenorrhea
of Technology, Cambridge, MA, USA; Department of Psychia- (2021)
try, Massachusetts General Hospital and Harvard Medical
School, Charlestown, MA, USA; Athinoula A. Martinos Center Chan, Hui-Ling; Low, Intan; Chen, Li-Fen; Chen, Yong-
for Biomedical Imaging, Massachusetts General Hospital and Sheng; Chu, Ian-Ting; Hsieh, Jen-Chuen
Harvard Medical School, Charlestown, MA, USA. Electronic
address: [email protected] Department of Computer Science, National Yang Ming Chiao
Tung University, Hsinchu, Taiwan; Integrated Brain Research
ABSTRACT Expectation can shape the perception of Unit, Department of Medical Research, Taipei Veterans
pain within a fraction of time, but little is known about General Hospital, Taipei, Taiwan; Institute of Biomedical In-
how perceived expectation unfolds over time and formatics, National Yang Ming Chiao Tung University, Taipei,
modulates pain perception. Here, we combine mag- Taiwan; Institute of Brain Science, National Yang Ming Chiao
netoencephalography (MEG) and machine learning Tung University, Taipei, Taiwan
approaches to track the neural dynamics of expecta-
tions of pain in healthy participants with both sexes. ABSTRACT Objective. Neural communication or the
We found that the expectation of pain, as conditioned interactions of brain regions play a key role in the
by facial cues, can be decoded from MEG as early as formation of functional neural networks. A type of
150 ms and up to 1100 ms after cue onset, but decod- neural communication can be measured in the form
ing expectation elicited by unconsciously perceived of phase-amplitude coupling (PAC), which is the
cues requires more time and decays faster compared to coupling between the phase of low-frequency oscilla-
consciously perceived ones. Also, results from tem- tions and the amplitude of high-frequency oscillations.
poral generalization suggest that neural dynamics of This paper presents a beamformer-based imaging
decoding cue-based expectation were predominately method, beamformer-based imaging of PAC (BIPAC),
sustained during cue presentation but transient after to quantify the strength of PAC between a seed region
cue presentation. Finally, although decoding expecta- and other brain regions.Approach. A dipole is used to
tion elicited by consciously perceived cues were based model the ensemble of neural activity within a group
on a series of time-restricted brain regions during cue of nearby neurons and represents a mixture of multiple
presentation, decoding relied on the medial prefrontal source components of cortical activity. From ensemble
cortex and anterior cingulate cortex after cue presenta- activity at each brain location, the source component
tion for both consciously and unconsciously perceived with the strongest coupling to the seed activity is
cues. These findings reveal the conscious and uncon- extracted, while unrelated components are suppressed
scious processing of expectation during pain anticipa- to enhance the sensitivity of coupled-source estima-
tion.Main results. In evaluations using simulation

 ontents  Index 245
C