Page 263 - MEGIN Book Of Abstracts - 2023

different therapies is important. In recent years, neuro- Benjamin T; Oh, Jiwon; Bhatia, Anuj; Inman, Robert D;
imaging techniques have become increasingly impor- Davis, Karen D
tant in basic and clinical pain research. Thanks to the
application and development of neuroimaging tech- Division of Brain, Imaging, and Behaviour, Krembil Brain
niques in the study of chronic pain in KOA, researchers Institute, University Health Network, Toronto, ON, Canada;
have found that chronic pain in KOA contains both Institute of Medical Science, University of Toronto, Toronto,
injury-receptive and neuropathic pain components. ON, Canada; Department of Medical Imaging, University
The neuropathic pain mechanism that causes KOA pain of Toronto, Toronto, ON, Canada; Division of Neurology,
is complicated, and it may be produced by peripheral Department of Medicine, St. Michael's Hospital, Toronto,
or central sensitization, but it has not gotten enough ON, Canada; Department of Anesthesia and Pain Medicine,
attention in clinical practice, and there is no agreement Toronto Western Hospital, and University of Toronto, Toronto,
on how to treat combination neuropathic pain KOA. ON, Canada; Division of Immunology, University of Toronto,
As a result, using neuroimaging techniques such as Toronto, ON, Canada; Department of Surgery, University of
magnetic resonance imaging (MRI), electroencepha- Toronto, Toronto, ON, Canada
lography (EEG), magnetoencephalography (MEG), and
near-infrared spectroscopy (NIRS), this review examines ABSTRACT Alpha oscillatory activity (8-13 Hz) is the
the changes in brain pathophysiology-related regions dominant rhythm in the awake brain and is known to
caused by KOA pain, compares the latest results in pain play an important role in pain states. Previous studies
assessment and prediction, and clarifies the central have identified alpha band slowing and increased pow-
brain analgesic mechanistic. The capsule network er in the dynamic pain connectome (DPC) of people
model is introduced in this paper from the perspec- with chronic neuropathic pain. However, a link between
tive of deep learning network structure to construct an alpha-band abnormalities and sex differences in brain
information-complete and reversible image low-level organization in healthy individuals and those with
feature bridge using isotropic representation, predict chronic pain is not known. Here, we used resting-state
the corresponding capsule features from MRI voxel magnetoencephalography to test the hypothesis that
responses, and then, complete the accurate reconstruc- peak alpha frequency (PAF) abnormalities are general
tion of simple images using inverse transformation. features across chronic central and peripheral condi-
The proposed model improves the structural similarity tions causing neuropathic pain but exhibit sex-specific
index by about 10%, improves the reconstruction per- differences in networks of the DPC (ascending nocicep-
formance of low-level feature content in simple images tive pathway [ANP], default mode network, salience
by about 10%, and achieves feature interpretation and network [SN], and subgenual anterior cingulate cortex).
analysis of low-level visual cortical fMRI voxels by visu- We found that neuropathic pain (N = 25 men and 25
alising capsule features, according to the experimental women) was associated with increased PAF power
results. in the DPC compared with 50 age- and sex-matched
healthy controls, whereas slower PAF in nodes of the
Computational and mathematical methods in medicine SN (temporoparietal junction) and the ANP (posterior
(2021), Vol. 2021 (34876922) (1 citation) insula) was associated with higher trait pain intensity.
In the neuropathic pain group, women exhibited lower
PAF power in the subgenual anterior cingulate cortex
Exploring sex differences in alpha brain activity as a and faster PAF in the ANP and SN than men. The within-
potential neuromarker associated with neuropathic sex analyses indicated that women had neuropathic
pain (2022) pain-related increased PAF power in the ANP, SN, and
default mode network, whereas men with neuropathic
Fauchon, Camille; Kim, Junseok A; El-Sayed, Rima; pain had increased PAF power restricted to the ANP.
Osborne, Natalie R; Rogachov, Anton; Cheng, Joshua These findings highlight neuropathic pain-related and
C; Hemington, Kasey S; Bosma, Rachael L; Dunkley, sex-specific abnormalities in alpha oscillations across

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C