Page 264 - MEGIN Book Of Abstracts - 2023

the DPC that could underlie aberrant neuronal commu- RESULTS All participants reported the interventions to
nication in nociceptive processing and modulation. be tolerable with no significant adverse effects dur-
ing the session. Paired DRGS/active tDCS resulted in a
Pain (2022), Vol. 163, No. 7 (34711764) (4 citations) significant reduction in pain scores compared to paired
DRGS-ON/sham tDCS or DRGS alone. There was no
difference in the additive effect of M1 vs. MEG-localized
Paired Acute Invasive/Non-invasive Stimulation tDCS. Significant augmentation of beta activity was ob-
(PAINS) study: A phase I/II randomized, sham- served between DRGS-OFF and DRGS-ON conditions,
controlled crossover trial in chronic neuropathic as well as between paired DRGS-ON/sham tDCS and
pain (2021) paired DRGS-ON/active tDCS.

Parker, Tariq; Raghu, Ashley; Huang, Yongzhi; Gillies, CONCLUSION Our results indicate that a single session
Martin J; FitzGerald, James J; Aziz, Tipu; Green, of tDCS alongside DRGS is safe and can significantly re-
Alexander L duce pain acutely in neuropathic pain patients. Paired
invasive/non-invasive neuromodulation is a promis-
Nuffield Department of Surgical Sciences, University of ing new treatment strategy for pain management
Oxford, Oxford, United Kingdom; Neurosurgery Department, and should be evaluated further to assess long-term
Massachusetts General Hospital, Boston, MA, USA. Electronic benefits.
address: [email protected]; Nuffield Department
of Surgical Sciences, University of Oxford, Oxford, United Keywords: Chronic pain, Dorsal root ganglion stimulation,
Kingdom; Academy of Medical Engineering and Translational EEG, Transcranial direct current stimulation
Medicine, Tianjin University, Tianjin, 300072, China
Brain stimulation (2021), Vol. 14, No. 6 (34673258) (2
BACKGROUND Dorsal root ganglion (DRG) stimulation, citations)
an invasive method of neuromodulation, and transcra-
nial direct current stimulation (tDCS), a non-invasive
method of altering cortical excitability, have both Migraine chronification is associated with beta-
proven effective in relieving chronic pain. band connectivity within the pain-related cortical
regions: a magnetoencephalographic study (2021)
OBJECTIVE We employed a randomized, sham-con-
trolled crossover study design to investigate whether Hsiao, Fu-Jung; Chen, Wei-Ta; Liu, Hung-Yu; Wang, Yen-
single-session tDCS would have an additive therapeutic Feng; Chen, Shih-Pin; Lai, Kuan-Lin; Hope Pan, Li-Ling;
effect alongside DRG stimulation (DRGS) in the treat- Coppola, Gianluca; Wang, Shuu-Jiun
ment of chronic pain.
Brain Research Center, National Yang-Ming University, Taipei,
METHODS Sixteen neuropathic pain patients who Taiwan; Department of Neurology, Neurological Institute,
were previously implanted with DRG stimulators were Taipei Veterans General Hospital, Taipei, Taiwan; Department
recruited. Baseline pain scores were established with of Medico-Surgical Sciences and Biotechnologies, Sapienza
DRGS-OFF. Pain scores were then recorded with DRGS- University of Rome Polo Pontino, Latina, Italy
ON, after paired sham tDCS stimulation, and after
paired active anodal tDCS (a-tDCS) stimulation. For ABSTRACT Pain disorders are associated with aber-
active tDCS, patients were randomized to 'MEG (mag- rant oscillations in the pain-related cortical regions;
netoencephalography) localized' tDCS or contralateral however, few studies have investigated the relationship
motor cortex (M1) tDCS for 30 min. EEG recordings and between the functional cortical network and migraine
evaluations of tDCS adverse effects were also collected. chronification through direct neural signals. Magneto-
encephalography was used to record the resting-state

 ontents  Index 243
C