Page 268 - MEGIN Book Of Abstracts - 2023

CONCLUSIONS Pain sensitivity in healthy individuals that pain sensitivity and pain interference were linked
is associated with the resting-state gamma oscillation to within- and cross-network broadband FCp across the
and functional connectivity in pain-related cortical Asc and SN. We also identified sex differences in these
regions. Further studies must be conducted in a large relationships: (a) women exhibited greater within-net-
population to confirm whether resting-state cortical work static FCp, whereas men had greater dynamic FCp
activities can be an objective measurement of pain within the dynamic pain connectome; (b) relationship
sensitivity in individuals without clinical pain. between pain sensitivity and pain interference with
FCp in women was commonly found in theta, whereas
Keywords: Episodic migraine, Functional connectivity, in men, these relationships were predominantly in the
Gamma, Magnetoencephalography, Oscillation, Pain beta and low gamma bands. These findings indicate
sensitivity, Resting state that dynamic interactions of brain networks underly-
ing pain involve fast brain communication in men but
The journal of headache and pain (2020), Vol. 21, No. 1 slower communication in women.
(33198621) (5 citations)
Keywords: functional connectivity, magnetoencephalog-
raphy, network dynamics, pain, sex differences
Sex-differences in network level brain dynamics
associated with pain sensitivity and pain Human brain mapping (2021), Vol. 42, No. 3 (33068500) (5
interference (2021) citations)

Kim, Junseok A; Bosma, Rachael L; Hemington, Kasey S;
Rogachov, Anton; Osborne, Natalie R; Cheng, Joshua C; Neural Oscillations: Understanding a Neural Code of
Dunkley, Benjamin T; Davis, Karen D Pain (2021)

Institute of Medical Science, Faculty of Medicine, University of Kim, Junseok A; Davis, Karen D
Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging
and Behaviour, Krembil Brain Institute, Krembil Research, In- Institute of Medical Science, Faculty of Medicine, University of
stitute, University Health Network, Toronto, Ontario, Canada; Toronto, Toronto, Ontario, Canada; Department of Surgery,
Neurosciences & Mental Health Program, The Hospital for University of Toronto, Toronto, Ontario, Canada
Sick Children Research Institute, Toronto, Ontario, Canada;
Department of Surgery, University of Toronto, Toronto, On- ABSTRACT Neural oscillations play an important role
tario, Canada in the integration and segregation of brain regions
that are important for brain functions, including pain.
ABSTRACT Neural dynamics can shape human experi- Disturbances in oscillatory activity are associated with
ence, including pain. Pain has been linked to dynamic several disease states, including chronic pain. Studies
functional connectivity within and across brain regions of neural oscillations related to pain have identified
of the dynamic pain connectome (consisting of the several functional bands, especially alpha, beta, and
ascending nociceptive pathway (Asc), descending anti- gamma bands, implicated in nociceptive processing. In
nociceptive pathway (Desc), salience network (SN), and this review, we introduce several properties of neural
the default mode network (DMN)), and also shows sex oscillations that are important to understand the role
differences. These linkages are based on fMRI-derived of brain oscillations in nociceptive processing. We also
slow hemodynamics. Here, we utilized the fine tempo- discuss the role of neural oscillations in the mainte-
ral resolution of magnetoencephalography (MEG) to nance of efficient communication in the brain. Finally,
measure resting state functional coupling (FCp) related we discuss the role of neural oscillations in healthy and
to individual pain perception and pain interference in chronic pain nociceptive processing. These data and
50 healthy individuals (26 women, 24 men). We found concepts illustrate the key role of regional and inter-

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