Page 271 - MEGIN Book Of Abstracts - 2023

Keywords: Pain, carpal tunnel syndrome, inferior parietal neuropathic inflammatory pain (non-NP) or when NP is
lobule, magnetoencephalography, spatial cognition also suspected. We measured resting-state magnetoen-
cephalography (MEG) spectral density in 45 people (17
NeuroRehabilitation (2020), Vol. 46, No. 3 (32250335) (1 females, 28 males) with chronic back pain due to anky-
citation) losing spondylitis (AS) and 38 age/sex matched healthy
controls. We used painDETECT scores to divide the
chronic pain group into those with only non-NP (NNP)
Abnormal alpha band power in the dynamic pain and those who likely also had a component of NP in ad-
connectome is a marker of chronic pain with a dition to their inflammatory pain. We also assessed pain
neuropathic component (2020) severity, pain interference, and disease activity with the
Brief Pain Inventory and Bath AS Disease Activity Index
Kisler, Lee B; Kim, Junseok A; Hemington, Kasey S; (BASDAI). We examined spectral power in the dynamic
Rogachov, Anton; Cheng, Joshua C; Bosma, Rachael L; pain connectome, including nodes of the ascending
Osborne, Natalie R; Dunkley, Benjamin T; Inman, Robert nociceptive pathway (ANP), default mode (DMN), and
D; Davis, Karen D salience networks (SN). Compared to the healthy con-
trols, the AS patients exhibited increased theta power
Division of Brain, Imaging, and Behaviour, Krembil Brain In- in the DMN and decreased low-gamma power in the
stitute, Krembil Research Institute, Toronto Western Hospital, DMN and ANP, but did not exhibit beta-band attenua-
University Health Network, Toronto, ON, Canada; Division of tion or peak-alpha slowing. The NNP patients were not
Brain, Imaging, and Behaviour, Krembil Brain Institute, Krem- different from HCs. Compared to both healthy controls
bil Research Institute, Toronto Western Hospital, University and NNP, NP patients had increased alpha power in
Health Network, Toronto, ON, Canada; Institute of Medical the ANP. Increased alpha power within the ANP was
Science, University of Toronto, Toronto, ON, Canada; Neu- associated with reduced BASDAI in the NNP group, and
rosciences & Mental Health Program, The Hospital for Sick increased pain in the mixed-NP group within the DMN,
Children Research Institute, Toronto, ON, Canada; Diagnostic SN, and ANP. Thus, high theta and low gamma activity
Imaging, The Hospital for Sick Children, Toronto, ON, Canada; may be markers of chronic pain but high alpha-band
Department of Medical Imaging, University of Toronto, activity may relate to particular features of neuropathic
Toronto, ON, Canada; Institute of Medical Science, University chronic pain.
of Toronto, Toronto, ON, Canada; Department of Medicine,
University of Toronto, Toronto, ON, Canada; Arthritis Institute, Keywords: Chronic pain, Default mode network, Magne-
Krembil Research Institute, University Health Network, Toron- toencephalography, Neuropathic pain, Salience network,
to, ON, Canada; Division of Brain, Imaging, and Behaviour, Somatosensory cortex
Krembil Brain Institute, Krembil Research Institute, Toronto
Western Hospital, University Health Network, Toronto, ON, NeuroImage. Clinical (2020), Vol. 26 (32203904) (20
Canada; Institute of Medical Science, University of Toronto, citations)
Toronto, ON, Canada; Department of Surgery, University of
Toronto, Toronto, ON, Canada; Surgery, University of Toronto,
Toronto, ON, Canada. Electronic address: karen.davis@ Cross-network coupling of neural oscillations in
uhnresearch.ca the dynamic pain connectome reflects chronic
neuropathic pain in multiple sclerosis (2020)
ABSTRACT We previously identified alpha frequency
slowing and beta attenuation in the dynamic pain con- Kim, Junseok A; Bosma, Rachael L; Hemington, Kasey S;
nectome related to pain severity and interference in pa- Rogachov, Anton; Osborne, Natalie R; Cheng, Joshua C;
tients with multiple sclerosis-related neuropathic pain Oh, Jiwon; Dunkley, Benjamin T; Davis, Karen D
(NP). Here, we determined whether these abnormali-
ties, are markers of aberrant temporal dynamics in non- Division of Brain, Imaging and Behaviour, Krembil Brain

 ontents  Index 250
C