Page 273 - MEGIN Book Of Abstracts - 2023

Acute Exercise Modulates Pain-induced Response Keywords: brain oscillations, electrical stimulation, exer-
on Sensorimotor Cortex ∼20 Hz Oscillation (2020) cise, magnetoencephalography, sensorimotor cortex

Hautasaari, Pekka; McLellan, Susanna; Koskio, Maija; Neuroscience (2020), Vol. 429 (31935493) (4 citations)
Pesonen, Heidi; Tarkka, Ina M

Faculty of Sport and Health Sciences, University of Jyväskylä, Bilateral activations in operculo-insular area show
Jyväskylä, Finland; Jyväskylä Centre for Interdisciplinary Brain temporal dissociation after peripheral electrical
Research, University of Jyväskylä, Jyväskylä, Finland. Elec- stimulation in healthy adults (2020)
tronic address: [email protected]
Hautasaari, Pekka; Saloranta, Harri; Savić, Andrej M;
ABSTRACT Exercise affects positively on self-reported Korniloff, Katariina; Kujala, Urho M; Tarkka, Ina M
pain in musculoskeletal pain conditions possibly via
top-down pain inhibitory networks. However, the role Jyväskylä Centre for Interdisciplinary Brain Research, Universi-
of cortical activity in these networks is unclear. The aim ty of Jyväskylä, Jyväskylä, Finland; Health Sciences, Faculty of
of the current exploratory study was to investigate the Sport and Health Sciences, University of Jyväskylä, Jyväskylä,
effects of acute exercise on cortical nociceptive pro- Finland; Tecnalia Serbia Ltd., Belgrade, Serbia
cessing and specifically the excitability in the human
sensorimotor cortex. Five healthy adults (mean age ABSTRACT Interhemispheric transfer is necessary for
32.8 years) were recorded with a whole-head 306-chan- sensory integration and coordination of body sides. We
nel magnetoencephalography (MEG, Elekta Neuromag® studied how somatosensory input from one body side
Triux™). Participant's right hand third fingertip was may reach both body sides. First, we investigated with
stimulated electrically with an intracutaneous non- 17 healthy adults in which uni- and bilateral brain areas
magnetic copper tip electrode before and immediately were involved in consecutive stages of automatic sen-
after an exercise task. Stimulus intensity was set indi- sory processing of non-nociceptive peripheral stimula-
vidually so that the stimulation was subjectively rated tion. Somatosensory evoked fields (SEFs) to electrical
as moderately painful, 6-7 on a visual analog scale. stimulation were recorded with 306-channel magne-
The acute exercise task was an isometric three-minute toencephalography in two conditions. First, SEFs were
fatiguing left hand contraction with force-level at 30% registered following sensory radial nerve (RN) stimula-
of maximum voluntary contraction. Data analysis was tion to dorsal surface of the right hand and second,
conducted as event-related evoked field and frequency following median nerve (MN) stimulation at the right
analysis. Early cortical activations after stimulation were wrist. Cortical activations were located in contralateral
localized in the primary and secondary somatosensory postcentral gyrus after MN and RN stimulations and in
cortices. The main result demonstrated modulation bilateral operculo-insular area after RN stimulation. First
of cortical nociceptive processing in the sensorimo- component occurred earlier after MN than RN stimula-
tor cortex ∼20 Hz rhythm immediately after the acute tion. Middle latency components had similar latencies
exercise. In conclusion, acute exercise may have an with stronger activation in contralateral postcentral
effect on nociceptive processing in the sensorimotor gyrus after MN than RN stimulation. Interestingly, long
cortex on oscillatory level. Research on cortical oscilla- latency components located in bilateral operculo-insu-
tions analyzing interaction between nociception and lar area after RN stimulation showed latency difference
exercise is limited. This study presents results indicating between hemispheres, i.e. activation peaked earlier in
brain oscillatory activity as a feasible research target for contralateral than in ipsilateral side. Additional experi-
examining mechanisms interacting between exercise ments comparing novel intracutaneous nociceptive,
and cortical nociceptive processing. RN and MN electrical stimuli confirmed bilateral long
latency activation elicited by each stimulus type and
highlighted latency differences between hemispheres.

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