Page 257 - MEGIN Book Of Abstracts - 2023

motor cortex, as measured by postmovement beta Science, Faculty of Medicine, University of Toronto, M5S1A8,
rebound amplitude associated with peak latency, was Toronto, Canada; Department of Surgery, University of
decreased in POMS, although this reduction was not Toronto, M5T1P5, Toronto, Canada. Electronic address: karen.
predicted by structural metrics. Our findings implicate davis@uhnresearch.ca
loss of WM integrity as a contributor to reduced electri-
cal responses in the visual cortex in POMS. Future work ABSTRACT Sensory perceptions are coded by complex
in larger cohorts will inform on the cognitive implica- neural dynamics of regional communication in the
tions of this finding in terms of visual processing func- brain. Thus, sensory abnormalities such as chronic pain
tion and will determine whether the progressive loss may occur when neural dynamics go awry. Previous
of brain volume known to occur in POMS ultimately studies of cross-network dynamic functional connectiv-
contributes to both progressive dysfunction in such ity in chronic pain identified abnormalities but were
tasks as well as progressive reduction in cortical electri- based on functional MRI which only captures slow tem-
cal responses in the visual cortex. poral features. Here we conducted a magnetoencepha-
lography (MEG) study to investigate fine temporal
Keywords: MEG, diffusion tensor imaging, magnetic reso- dynamics of aberrant cross-regional and cross-network
nance imaging, multiple sclerosis, pediatrics, postmove- communication of the dynamic pain connectome in
ment beta rebound, visual gamma band patients with chronic pain. We also introduced a novel
measure, dynamic functional coupling, to quantify
Human brain mapping (2020), Vol. 41, No. 15 (32648649) the variability of brain communication. The study was
(6 citations) performed in 33 people who had chronic pain associ-
ated with multiple sclerosis and 30 healthy controls. We
found that patients with chronic pain exhibited abnor-
Cross-network coupling of neural oscillations in malities in cross-network functional coupling across
the dynamic pain connectome reflects chronic multiple frequency bands (theta, alpha, beta, gamma),
neuropathic pain in multiple sclerosis (2020) between the salience network and 3 other networks:
the ascending nociceptive pathway, descending anti-
Kim, Junseok A; Bosma, Rachael L; Hemington, Kasey S; nociceptive pathway, and the default mode network.
Rogachov, Anton; Osborne, Natalie R; Cheng, Joshua C; However, these cross-network abnormalities involved
Oh, Jiwon; Dunkley, Benjamin T; Davis, Karen D different frequency bands in patients with neuropathic
versus non-neuropathic chronic pain. Furthermore,
Division of Brain, Imaging and Behaviour, Krembil Brain cross-network abnormalities were linked to pain sever-
Institute, Krembil Research Institute, University Health Net- ity and pain interference. Our findings implicate broad-
work, M5T2S8, Toronto, Canada; Institute of Medical Science, band cross-network abnormalities as hallmark features
Faculty of Medicine, University of Toronto, M5S1A8, Toronto, of chronic pain in multiple sclerosis.
Canada; Division of Neurology, Department of Medicine, St.
Michael's Hospital, M5B1W8, Toronto, Canada; Department Keywords: Chronic pain, Dynamic functional coupling,
of Medical Imaging, University of Toronto, M5T1W7, Toronto, Functional connectivity, Magnetoencephalography, Oscil-
Canada; Neurosciences & Mental Health Program, The Hos- lations
pital for Sick Children Research Institute, M5G0A4, Toronto,
Canada; Division of Brain, Imaging and Behaviour, Krembil NeuroImage. Clinical (2020), Vol. 26 (32143136) (15
Brain Institute, Krembil Research Institute, University Health citations)
Network, M5T2S8, Toronto, Canada; Institute of Medical

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