Page 252 - MEGIN Book Of Abstracts - 2023

a principled way to merge magnetoencephalography for Neurology and Neurosurgery and the UCL Queen Square
(MEG)/electroencephalography (EEG) and tractography. Institute of Neurology, London, United Kingdom

Keywords: brain criticality, brain dynamics, brain networks, BACKGROUND Impaired eye movements in multiple
conduction velocities, magnetoencephalography, mul- sclerosis (MS) are common and could represent a non-
tiple sclerosis invasive and accurate measure of (dys)functioning of
interconnected areas within the complex brain net-
The Journal of neuroscience: the official journal of the work. The aim of this study was to test whether altered
Society for Neuroscience (2022), Vol. 42, No. 47 (36241383) saccadic eye movements are related to changes in
(1 citation) functional connectivity (FC) in patients with MS.

METHODS Cross-sectional eye movement (pro-
Impaired saccadic eye movements in multiple saccades and anti-saccades) and magnetoencepha-
sclerosis are related to altered functional lography (MEG) data from the Amsterdam MS cohort
connectivity of the oculomotor brain network were included from 176 MS patients and 33 healthy
(2021) controls. FC was calculated between all regions of
the Brainnetome atlas in six conventional frequency
Nij Bijvank, J A; Strijbis, E M M; Nauta, I M; Kulik, S bands. Cognitive function and disability were evaluated
D; Balk, L J; Stam, C J; Hillebrand, A; Geurts, J J G; by previously validated measures. The relationships
Uitdehaag, B M J; van Rijn, L J; Petzold, A; Schoonheim, between saccadic parameters and both FC and clinical
M M scores in MS patients were analysed using multivariate
linear regression models.
Amsterdam UMC, Vrije Universiteit Amsterdam, Depart-
ment of Neurology, MS Center and Neuro-ophthalmology RESULTS In MS pro- and anti-saccades were abnormal
Expertise Center, Amsterdam Neuroscience, Amsterdam, the compared to healthy controls A relationship of saccadic
Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, eye movements was found with FC of the oculomo-
Department of Ophthalmology, Neuro-ophthalmology tor network, which was stronger for regional than
Expertise Center, Amsterdam Neuroscience, Amsterdam, global FC. In general, abnormal eye movements were
the Netherlands. Electronic address: j.nijbijvank@amsterda- related to higher delta and theta FC but lower beta FC.
mumc.nl; Amsterdam UMC, Vrije Universiteit Amsterdam, Strongest associations were found for pro-saccadic
Department of Anatomy and Neurosciences, Amsterdam, the latency and FC of the precuneus (beta band β = -0.23,
Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, p = .006), peak velocity and FC of the parietal eye field
Department of Clinical Neurophysiology and Magnetoen- (theta band β = -0.25, p = .005) and gain and FC of the
cephalography Center, Amsterdam Neuroscience, Amster- inferior frontal eye field (theta band β = -0.25, p = .003).
dam, the Netherlands; Amsterdam UMC, Vrije Universiteit Pro-saccadic latency was also strongly associated with
Amsterdam, Department of Ophthalmology, Neuro-ophthal- disability scores and cognitive dysfunction.
mology Expertise Center, Amsterdam Neuroscience, Amster-
dam, the Netherlands; Onze Lieve Vrouwe Gasthuis, Depart- CONCLUSIONS Impaired saccadic eye movements
ment of Ophthalmology, Amsterdam, the Netherlands; were related to functional connectivity of the oculo-
Amsterdam UMC, Vrije Universiteit Amsterdam, Department motor network and clinical performance in MS. This
of Neurology, MS Center and Neuro-ophthalmology Expertise study also showed that, in addition to global network
Center, Amsterdam Neuroscience, Amsterdam, the Neth- connectivity, studying regional changes in MEG studies
erlands; Amsterdam UMC, Vrije Universiteit Amsterdam, could yield stronger correlations.
Department of Ophthalmology, Neuro-ophthalmology
Expertise Center, Amsterdam Neuroscience, Amsterdam, the
Netherlands; Moorfields Eye Hospital, The National Hospital

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