Page 249 - MEGIN Book Of Abstracts - 2023

Multiple Sclerosis

Magnetization transfer saturation reveals saturation (MTsat) is an advanced magnetic resonance
subclinical optic nerve injury in pediatric-onset imaging (MRI) parameter sensitive to myelin density
multiple sclerosis (2023) and microstructural integrity, which can be applied to
the study of the ON.
Longoni, Giulia; Martinez Chavez, Edgar; Young,
Kimberly; Brown, Robert A; Bells, Sonya; Fetco, OBJECTIVE The objective of this study was to investi-
Dumitru; Kim, Laura; Grover, Stephanie A; Costello, gate the presence of subclinical ON abnormalities in
Fiona; Reginald, Arun; Bar-Or, Amit; Marrie, Ruth Ann; pediatric-onset MS by means of magnetization transfer
Arnold, Douglas L; Narayanan, Sridar; Branson, Helen M; saturation and evaluate their association with other
Banwell, Brenda L; Sled, John G; Mabbott, Donald J; Yeh, structural and functional parameters of visual pathway
E Ann integrity.

Division of Neurology, Department of Pediatrics, University of METHODS Eleven youth living with pediatric-onset MS
Toronto, Toronto, ON, Canada/Department of Neurosciences (ylPOMS) and no previous history of optic neuritis and
and Mental Health, The Hospital for Sick Children, Toronto, 18 controls underwent standardized brain MRI, optical
ON, Canada; ShadowLab Research Inc., Toronto, ON, Cana- coherence tomography (OCT), Magnetoencephalogra-
da; McConnell Brain Imaging Centre, Montreal Neurological phy (MEG)-Visual Evoked Potentials (VEPs), and visual
Institute and Hospital, McGill University, Montreal, QC, Cana- battery. Data were analyzed with mixed effect models.
da; Departments of Clinical Neurosciences and Surgery, Cum-
ming School of Medicine, University of Calgary, Calgary, AB, RESULTS While ON volume, OCT parameters, oc-
Canada; Department of Ophthalmology and Visual Sciences, cipital MEG-VEPs outcomes, and visual function did
The University of Toronto, Toronto, ON, Canada; Department not differ significantly between ylPOMS and controls,
of Neurology, Perelman School of Medicine, University of ylPOMS had lower MTsat in the supratentorial normal
Pennsylvania, Philadelphia, PA, USA; Departments of Internal appearing white matter (-0.26 nU, p = 0.0023), and in
Medicine and Community Health Sciences, Max Rady College both in the ON (-0.62 nU, p < 0.001) and in the normal
of Medicine, Rady Faculty of Health Sciences, University of appearing white matter of the optic radiation (-0.56
Manitoba, Winnipeg, MB, Canada; McConnell Brain Imaging nU, p = 0.00071), with these being positively correlated
Centre, Montreal Neurological Institute and Hospital, McGill (+0.57 nU, p = 0.00037).
University, Montreal, QC, Canada/Department of Neurol-
ogy and Neurosurgery, Montreal Neurological Institute and CONCLUSIONS Subclinical microstructural injury
Hospital, McGill University, Montreal, QC, Canada; Depart- affects the ON of ylPOMS. This may appear as MTsat
ment of Diagnostic Imaging, University of Toronto, Toronto, changes before being detectable by other currently
ON, Canada; Division of Neurology, The Children's Hospital available testing.
of Philadelphia, Perelman School of Medicine, University of
Pennsylvania, Philadelphia, PA, USA; Department of Medical Keywords: Pediatric MS, magnetization transfer, optic
Biophysics, University of Toronto, Toronto, ON, Canada nerve, optical coherence tomography, quantitative MRI,
visual functions
BACKGROUND The presence of subclinical optic nerve
(ON) injury in youth living with pediatric-onset MS Multiple sclerosis (Houndmills, Basingstoke, England)
has not been fully elucidated. Magnetization transfer (2023), Vol. 29, No. 2 (36545918) (0 citations)

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