Page 247 - MEGIN Book Of Abstracts - 2023

Shanghai, 200025, China. Electronic address: sbm11224@ Motor effects of deep brain stimulation correlate
rjh.com.cn; Wellcome Centre for Human Neuroimaging, UCL with increased functional connectivity in
Queen Square Institute of Neurology, London WC1N 3BG, UK. Parkinson's disease: An MEG study (2020)
Electronic address: [email protected]
Boon, Lennard I; Hillebrand, Arjan; Potters, Wouter V; de
ABSTRACT Parkinson's disease (PD) is a movement Bie, Rob M A; Prent, Naomi; Bot, Maarten; Schuurman,
disorder caused by dopaminergic neurodegenera- P Richard; Stam, Cornelis J; van Rootselaar, Anne-Fleur;
tion. Levodopa (L-dopa) is an effective medication Berendse, Henk W
for alleviating motor symptoms in PD that has been
shown previously to reduce subcortical beta (13-30 Hz) Amsterdam UMC, Vrije Universiteit Amsterdam, Neurology,
oscillations. How L-dopa influences oscillations in the Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam,
motor cortex is unclear. In this study, 21 PD patients the Netherlands; Amsterdam UMC, Vrije Universiteit Amster-
were recorded with magnetoencephalography (MEG) dam, Clinical Neurophysiology and Magnetoencephalog-
in L-dopa ON and OFF states. Oscillatory components raphy Centre, Amsterdam Neuroscience, De Boelelaan 1117,
of resting-state power spectra were compared between Amsterdam, the Netherlands. Electronic address: l.i.boon@
the two states and the significant effect was localized amsterdamumc.nl; Amsterdam UMC, University of Amster-
using beamforming. Unified Parkinson's Disease Rat- dam, Neurology and Clinical Neurophysiology, Amsterdam
ing Scale (UPDRS) III akinesia and rigidity sub-scores Neuroscience, Meibergdreef 9, Amsterdam, the Netherlands;
for the most affected hemibody were correlated with Amsterdam UMC, University of Amsterdam, Neurosurgery,
source power values for the contralateral hemisphere. Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, the
An L-dopa-induced power increase was found over Netherlands
the central sensors significant in the 18-30 Hz range
(F(1,20) > 14.8, PFWE corr < 0.05, cluster size inference ABSTRACT Deep brain stimulation (DBS) of the sub-
with P = 0.001 cluster-forming threshold). Beamform- thalamic nucleus (STN) is an established symptomatic
ing localization of this effect revealed distinct peaks at treatment in Parkinson's disease, yet its mechanism
the bilateral sensorimotor cortex. A significant cor- of action is not fully understood. Locally in the STN,
relation between the magnitude of L-dopa induced stimulation lowers beta band power, in parallel with
18-30 Hz oscillatory motor-cortical power increase symptom relief. Therefore, beta band oscillations
and the degree of improvement in contralateral are sometimes referred to as "anti-kinetic". However,
akinesia and rigidity was found (F(2, 19) = 4.9, pone- in recent studies functional interactions have been
tailed = 0.02, R[2] = 0.2). Power in the same range was observed beyond the STN, which we hypothesized
also inversely correlated with combined akinesia and to reflect clinical effects of DBS. Resting-state, whole-
rigidity scores in the L-dopa OFF state (F(2, 19) = 9.2, brain magnetoencephalography (MEG) recordings and
ptwo-tailed = 0.007, R[2] = 0.33) but not in the L-dopa assessments on motor function were obtained in 18
ON state (F(2, 19) = 0.27, ptwo-tailed = 0.6, R[2] = 0.01). Parkinson's disease patients with bilateral STN-DBS, on
These results suggest that the role of motor cortical and off stimulation. For each brain region, we estimat-
beta oscillations in PD is distinct from that of subcorti- ed source-space spectral power and functional connec-
cal beta. tivity with the rest of the brain. Stimulation led to an
increase in average peak frequency and a suppression
Keywords: Cortex, Dopamine, Human, M1, Movement of absolute band power (delta to low-beta band) in the
disorders sensorimotor cortices. Significant changes (decreases
and increases) in low-beta band functional connectivity
NeuroImage. Clinical (2020), Vol. 26 (32361482) (10 were observed upon stimulation. Improvement in bra-
citations) dykinesia/rigidity was significantly related to increases
in alpha2 and low-beta band functional connectivity
(of sensorimotor regions, the cortex as a whole, and

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