Page 244 - MEGIN Book Of Abstracts - 2023

Keywords: Apathy, Deep brain stimulation, Functional cal issues associated with EEG/MEG recordings in DBS
connectivity, Magnetoencephalography, Parkinson’s patients and the experimental findings to date. One
disease major line of research is simultaneous recording of local
field potentials (LFPs) from DBS targets and EEG/MEG.
Brain stimulation (2021), Vol. 14, No. 1 (33385593) (5 These studies revealed a set of cortico-subcortical co-
citations) herent networks functioning at distinguishable physi-
ological frequencies. Specific network responses were
linked to clinical state, task or stimulation parameters.
EEG and MEG primers for tracking DBS network Another experimental approach is mapping of DBS-
effects (2021) targeted networks in chronically implanted patients
by recording EEG/MEG responses during stimulation.
Litvak, Vladimir; Florin, Esther; Tamás, Gertrúd; Groppa, One can track responses evoked by single stimulation
Sergiu; Muthuraman, Muthuraman pulses or bursts as well as brain state shifts caused
by DBS. These studies have the potential to provide
The Wellcome Centre for Human Neuroimaging, UCL Queen biomarkers for network responses that can be adapted
Square Institute of Neurology, London, UK; Institute of Clini- to guide stereotactic implantation or optimization of
cal Neuroscience and Medical Psychology, Medical Faculty, stimulation parameters. This is especially important for
Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; diseases where the clinical effect of DBS is delayed or
Department of Neurology, Semmelweis University, Buda- develops slowly over time. The same biomarkers could
pest, Hungary; Movement disorders and Neurostimulation, also potentially be utilized for the online control of DBS
Biomedical Statistics and Multimodal Signal Processing Unit, network effects in the new generation of closed-loop
Department of Neurology, University Medical Center of the stimulators that are currently entering clinical use.
Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Through future studies, the use of network biomarkers
Mainz, Germany; Movement disorders and Neurostimulation, may facilitate the integration of circuit physiology into
Biomedical Statistics and Multimodal Signal Processing Unit, clinical decision making.
Department of Neurology, University Medical Center of the
Johannes Gutenberg University, Langenbeckstrasse 1, 55131 NeuroImage (2021), Vol. 224 (33059051) (12 citations)
Mainz, Germany. Electronic address: mmuthura@uni-mainz.
de
Clinical factors affecting evoked magnetic fields in
ABSTRACT Deep brain stimulation (DBS) is an effec- patients with Parkinson's disease (2020)
tive treatment method for a range of neurological
and psychiatric disorders. It involves implantation of Naganuma, Ryoji; Yabe, Ichiro; Takeuchi, Megumi;
stimulating electrodes in a precisely guided fashion Morishita, Kirari; Nakane, Shingo; Takase, Ryoken;
into subcortical structures and, at a later stage, chronic Takahashi-Iwata, Ikuko; Matsushima, Masaaki; Otsuki,
stimulation of these structures with an implantable Mika; Shiraishi, Hideaki; Sasaki, Hidenao
pulse generator. While the DBS surgery makes it pos-
sible to both record brain activity and stimulate parts Department of Neurology, Faculty of Medicine and Graduate
of the brain that are difficult to reach with non-invasive School of Medicine, Hokkaido University, Sapporo, Hokkaido,
techniques, electroencephalography (EEG) and mag- Japan; Division of Laboratory and Transfusion Medicine, Hok-
netoencephalography (MEG) provide complementary kaido University Hospital, Sapporo, Hokkaido, Japan; Division
information from other brain areas, which can be used of Magnetoencephalography, Hokkaido University Hospital,
to characterize brain networks targeted through DBS. Sapporo, Hokkaido, Japan; Department of Radiation Tech-
This requires, however, the careful consideration of dif- nology, Sapporo City General Hospital, Sapporo, Hokkaido,
ferent types of artifacts in the data acquisition and the Japan; Faculty of Health Sciences/Graduate School of Health
subsequent analyses. Here, we review both the techni- Sciences/Department of Health Sciences, School of Medicine,

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