Page 239 - MEGIN Book Of Abstracts - 2023

values in PD patients with cognitive impairment as dopamine caused the beta band activity to switch from
compared with both cognitively unimpaired patients an STN-mediated motor network to a frontoparietal-
and healthy subjects. Further, using graph analysis, we mediated one. In contrast, dopamine did not modify
analyzed alterations in brain network topology that local STN-STN coherence in PD. STN-STN synchrony
were related to cognitive functioning. emerged both on and off medication. By providing
electrophysiological evidence for the differential effects
Keywords: brain networks topology, cognition, functional of dopaminergic medication on the discovered net-
connectivity, graph theory, magnetoencephalography, works, our findings open further avenues for electrical
synchrony and pharmacological interventions in PD.

Brain connectivity (2022), Vol. 12, No. 5 (34269602) (4 Keywords: human, local field potential, magnetoencepha-
citations) lography, neuroscience, time-resolved analysis, whole-
brain

Differential dopaminergic modulation of eLife (2021), Vol. 10 (34085932) (4 citations)
spontaneous cortico-subthalamic activity in
Parkinson's disease (2021)
STN-DBS affects language processing differentially
Sharma, Abhinav; Vidaurre, Diego; Vesper, Jan; in Parkinson's disease: Multiple-case MEG study
Schnitzler, Alfons; Florin, Esther (2021)

Institute of Clinical Neuroscience and Medical Psychology, Hyder, Rasha; Højlund, Andreas; Jensen, Mads; Johnsen,
Medical Faculty, Heinrich-Heine University Düsseldorf, Düs- Erik L; Østergaard, Karen; Shtyrov, Yury
seldorf, Germany; Department of Clinical Health, Aarhus
University, Aarhus, Denmark; Department of Neurosurgery, Institute of Clinical Neuroscience and Medical Psychology,
University Hospital Düsseldorf, Düsseldorf, Germany; Depart- Medical Faculty, Heinrich-Heine University Düsseldorf, Ger-
ment of Neurology, Center for Movement Disorders and many; Center of Functionally Integrative Neuroscience (CFIN),
Neuromodulation, Medical Faculty, Heinrich-Heine University Department of Clinical Medicine, Aarhus University, Aarhus,
Düsseldorf, Düsseldorf, Germany Denmark; Research Unit for Robophilosophy and Integrative
Social Robotics, Interacting Minds Centre, Aarhus Univer-
ABSTRACT Pathological oscillations including elevated sity, Aarhus, Denmark; Department of Neurology, Aarhus
beta activity in the subthalamic nucleus (STN) and University Hospital, Aarhus, Denmark; Sano Private Hospi-
between STN and cortical areas are a hallmark of neural tal, Denmark; Centre for Cognition and Decision Making,
activity in Parkinson's disease (PD). Oscillations also Institute for Cognitive Neuroscience, HSE University, Moscow,
play an important role in normal physiological process- Russian Federation
es and serve distinct functional roles at different points
in time. We characterised the effect of dopaminergic OBJECTIVES In this study, we investigated the effects
medication on oscillatory whole-brain networks in of bilateral and unilateral deep brain stimulation of the
PD in a time-resolved manner by employing a hidden subthalamic nucleus (STN-DBS) in PD patients on neu-
Markov model on combined STN local field potentials ral responses associated with two aspects of spoken
and magnetoencephalography (MEG) recordings language processing: semantics of action-related verbs
from 17 PD patients. Dopaminergic medication led to and morphosyntactic processing.
coherence within the medial and orbitofrontal cortex
in the delta/theta frequency range. This is in line with MATERIALS AND METHODS Using a passive unat-
known side effects of dopamine treatment such as tended paradigm to present spoken linguistic stimuli,
deteriorated executive functions in PD. In addition, we recorded magnetoencephalographic (MEG) re-

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C