Page 238 - MEGIN Book Of Abstracts - 2023

using magnetoencephalography during an auditory- ABSTRACT Aim: The aim of the present study is to
motor task to understand the underlying mechanisms. investigate the relationship between both functional
The Grooved Pegboard, the UPDRS III finger tap, and connectivity and brain networks with cognitive decline,
the finger-thumb opposition will be assessed to inves- in patients with Parkinson's disease (PD). Introduction:
tigate clinical changes related to fine motor function. PD phenotype is not limited to motor impairment but,
This project will also serve to confirm or refute our pilot rather, a wide range of non-motor disturbances can oc-
data findings suggesting NMT relies on compensatory cur, with cognitive impairment being one of the most
brain networks utilized by the PD brain to bypass the common. However, how the large-scale organization of
dysfunctional basal ganglia. brain activity differs in cognitively impaired patients, as
opposed to cognitively preserved ones, remains poorly
DISCUSSION This study aims to use standardized understood. Methods: Starting from source-recon-
TIMP and OT research protocols for investigating the structed resting-state magnetoencephalography data,
neuronal pathways utilized by each intervention and we applied the phase linearity measurement (PLM) to
possibly study their efficacy with respect to fine motor estimate functional connectivity, globally and between
rehabilitation via a randomized control trial in the PD brain areas, in PD patients with and without cognitive
population. impairment (respectively PD-CI and PD-NC), as com-
pared with healthy subjects (HS). Further, using graph
TRIAL REGISTRATION ClinicalTrials.gov NCT03049033 . analysis, we characterized the alterations in brain net-
Registered on September 29, 2020. work topology and related these, as well as the func-
tional connectivity, to cognitive performance. Results:
Keywords: Magnetoencephalography, Motor cortical We found reduced global and nodal PLM in several
activity, Neurologic music therapy, Neuronal entrainment, temporal (fusiform gyrus, Heschl's gyrus, and inferior
Parkinson’s disease, Rehabilitation temporal gyrus), parietal (postcentral gyrus), and oc-
cipital (lingual gyrus) areas within the left hemisphere,
Trials (2021), Vol. 22, No. 1 (34454592) (1 citation) in the gamma band, in PD-CI patients, as compared
with PD-NC and HS. With regard to the global topologi-
cal features, PD-CI patients, as compared with HS and
Brain Networks and Cognitive Impairment in PD-NC patients, showed differences in multi-frequen-
Parkinson's Disease (2022) cies bands (delta, alpha, gamma) in the Leaf fraction,
Tree hierarchy (Th) (both higher in PD-CI), and Diameter
Rucco, Rosaria; Lardone, Anna; Liparoti, Marianna; (lower in PD-CI). Finally, we found statistically signifi-
Lopez, Emahnuel Troisi; De Micco, Rosa; Tessitore, cant correlations between the Montreal Cognitive As-
Alessandro; Granata, Carmine; Mandolesi, Laura; sessment test and both the Diameter in delta band and
Sorrentino, Giuseppe; Sorrentino, Pierpaolo the Th in the alpha band. Conclusion: Our work points
to specific large-scale rearrangements that occur selec-
Institute for Applied Science and Intelligent Systems, National tively in cognitively compromised PD patients and are
Research Council, Pozzuoli, Italy; Department of Social and correlated to cognitive impairment. Impact statement
Developmental Psychology, University of Rome "Sapienza," In this article, we want to test the hypothesis that the
Rome, Italy; Department of Motor Sciences and Wellness, cognitive decline observed in Parkinson's disease (PD)
University of Naples Parthenope, Naples, Italy; Department patients may be related to specific changes of both
of Advanced Medical and Surgical Sciences, University of functional connectivity and brain network topology.
Campania "Luigi Vanvitelli," Naples, Italy; Department of Specifically, starting from magnetoencephalography
Humanistic Studies, University of Naples Federico II, Naples, signals and by applying the phase linearity measure-
Italy; Hermitage-Capodimonte Hospital, Naples, Italy; Institut ment (PLM), a connectivity metric that measures the
de Neurosciences des Systèmes, Aix-Marseille University, synchronization between brain regions, we were able
Marseille, France to highlight differences in the global and nodal PLM

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