Page 233 - MEGIN Book Of Abstracts - 2023

amplitude coupling in the sensorimotor cortices corre- Keywords: Antisaccade, Executive function, Eye-tracking,
lated significantly with motor symptoms of Parkinson's Impulsivity, Inhibition control, Parkinson’s disease
disease (P < 0.05); beta- and gamma-band power did
not. We thus demonstrated that beta-gamma phase- Behavioural brain research (2022), Vol. 422 (35063499) (0
amplitude coupling in the resting state characterizes citations)
Parkinson's disease.

Scientific reports (2022), Vol. 12, No. 1 (35115607) (2 Profiling Parkinson's disease cognitive phenotypes
citations) via resting-state magnetoencephalography (2022)

Simon, Olivier B; Rojas, Donald C; Ghosh, Debashis;
Neural correlates of impaired response inhibition in Yang, Xinyi; Rogers, Sarah E; Martin, Christine S; Holden,
the antisaccade task in Parkinson's disease (2022) Samantha K; Kluger, Benzi M; Buard, Isabelle

Waldthaler, Josefine; Vinding, Mikkel C; Eriksson, Allison; Department of Biostatistics and Informatics, University of
Svenningsson, Per; Lundqvist, Daniel Colorado Denver, Aurora, Colorado; Department of Psychol-
ogy, Colorado State University, Fort Collins, Colorado; Depart-
Department of Neurology, University Hospital Marburg, ment of Neurology, University of Colorado Denver, Aurora,
Marburg, Germany; Department of Clinical Neuroscience, Colorado; Department of Neurology, University of Rochester
Karolinska Institutet, Stockholm, Sweden. Electronic address: Medical Center Rochester, Rochester, New York
[email protected]; NatMEG, Department of Clinical
Neuroscience, Karolinska Institutet, Stockholm, Sweden ABSTRACT Aberrant brain oscillations are a hallmark
of Parkinson's disease (PD) pathophysiology and may
ABSTRACT Deficits in response inhibition are a central be related to both motor and nonmotor symptoms.
feature of the highly prevalent dysexecutive syn- Mild cognitive impairment (MCI) affects many people
drome found in Parkinson's disease (PD). Such deficits with PD even at the time of diagnosis and conversion
are related to a range of common clinically relevant risks to PD dementia (PDD) are very high. Unfortu-
symptoms including cognitive impairment as well as nately, pharmacotherapies are not addressing cognitive
impulsive and compulsive behaviors. In this study, we symptoms in PD. Profiling PD cognitive phenotypes
explored the cortical dynamics underlying response (e.g., MCI, PDD, etc.) may therefore help inform future
inhibition during the mental preparation for the treatments. Neurophysiological methods, such as
antisaccade task by recording magnetoencephalogra- magnetoencephalography (MEG), offer the advantage
phy (MEG) and eye-movements in 21 non-demented of observing oscillatory patterns, whose regional and
patients with early to mid-stage Parkinson's disease temporal profiles may elucidate how cognitive changes
and 21 age-matched healthy control participants (HC). relate to neural mechanisms. We conducted a resting-
During the pre-stimulus preparatory period for antisac- state MEG cross-sectional study of 89 persons with
cades we observed: Taken together, the results indicate PD stratified into three phenotypic groups: normal
that alterations in pre-stimulus prefrontal alpha and cognition, MCI, and PDD, to identify brain regions
beta activity hinder proactive response inhibition and frequencies most associated with each cognitive
and in turn result in higher error rates and prolonged profile. In addition, a neuropsychological battery was
response latencies in PD. administered to assess each domain of cognition. Our
data showed higher power in lower frequency bands
(delta and theta) observed along with more severe
cognitive impairment and associated with memory,
language, attention, and global cognition. Of the total
119 brain parcels assessed during source analysis, wide-

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