Page 231 - MEGIN Book Of Abstracts - 2023

Department of Neurology, LSU Health Shreveport, Shreve- Deep brain stimulation of subthalamic nucleus
port, Louisiana, United States of America; LSU Health modulates cortical auditory processing in advanced
Shreveport Center for Brain Health, Shreveport, Louisiana, Parkinson's Disease (2022)
United States of America; Department of Psychology, UC
Berkeley, Berkeley, California, United States of America; Action Valkonen, Kati; Mäkelä, Jyrki P; Airaksinen, Katja;
Brain and Cognition Laboratory, Department of Psychol- Nurminen, Jussi; Kivisaari, Riku; Renvall, Hanna;
ogy, and fMRIotago, University of Otago, Dunedin, New Pekkonen, Eero
Zealand; Department of Neurobiology and Center for the
Neural Basis of Cognition University of Pittsburgh, Pittsburgh, BioMag Laboratory, Helsinki University Hospital Medical Im-
Pennsylvania, United States of America; Department of aging Center, Helsinki University Hospital, Helsinki University
Psychiatry, UC Davis, Sacramento, California, United States of and Aalto University School of Science, Helsinki, Finland;
America; Department of Radiology and Biomedical Imag- Department of Neurology, Helsinki University Hospital,
ing, University of California, San Francisco, California, United Finland and Department of Clinical Neurosciences (Neurol-
States of America; Department of Neurosurgery, LSU Health ogy), University of Helsinki, Helsinki, Finland; Department of
Shreveport, Shreveport, Louisiana, United States of America; Neurosurgery, Helsinki University Hospital, Helsinki, Finland;
Department of Neurology, UC Davis, Sacramento, California, Department of Neuroscience and Biomedical Engineering,
United States of America Aalto University, Espoo, Finland

ABSTRACT Response activation and inhibition are ABSTRACT Deep brain stimulation (DBS) has proven its
functions fundamental to executive control that are clinical efficacy in Parkinson's disease (PD), but its exact
disrupted in Parkinson disease (PD). We used magneto- mechanisms and cortical effects continue to be unclear.
encephalography to examine event related changes in Subthalamic (STN) DBS acutely modifies auditory
oscillatory power amplitude, peak latency and fre- evoked responses, but its long-term effect on auditory
quency in cortical networks subserving these functions cortical processing remains ambiguous. We studied
and identified abnormalities associated with PD. Partici- with magnetoencephalography the effect of long-
pants (N = 18 PD, 18 control) performed a cue/target term STN DBS on auditory processing in patients with
task that required initiation of an un-cued movement advanced PD. DBS resulted in significantly increased
(activation) or inhibition of a cued movement. Reac- contra-ipsilateral auditory response latency difference
tion times were variable but similar across groups. Task at ~100 ms after stimulus onset compared with preop-
related responses in gamma, alpha, and beta power erative state. The effect is likely due to normalization
were found across cortical networks including motor of neuronal asynchrony in the auditory pathways. The
cortex, supplementary and pre- supplementary motor present results indicate that STN DBS in advanced PD
cortex, posterior parietal cortex, prefrontal cortex and patients has long-lasting effects on cortical areas out-
anterior cingulate. PD-related changes in power and side those confined to motor processing. Whole-head
latency were noted most frequently in the beta band, magnetoencephalography provides a feasible tool to
however, abnormal power and delayed peak latency in study motor and non-motor neural networks in PD, and
the alpha band in the pre-supplementary motor area to track possible changes related to cortical reorganiza-
was suggestive of a compensatory mechanism. PD tion or plasticity induced by DBS.
peak power was delayed in pre-supplementary motor
area, motor cortex, and medial frontal gyrus only for PloS one (2022), Vol. 17, No. 2 (35202426) (1 citation)
activation, which is consistent with deficits in un-cued
(as opposed to cued) movement initiation characteris-
tic of PD.

PloS one (2022), Vol. 17, No. 3 (35245294) (0 citations)

 ontents  Index 210
C